| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Assessment of periportal fibrosis in Schistosomiasis mansoni patients by proton nuclear magnetic resonance-based metabonomics models
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Milena Lima Rodrigues, Tatiane Priscila Santos Rodrigues da Luz, Caroline Louise Diniz Pereira, Andrea Dória Batista, Ana Lúcia Coutinho Domingues, Ricardo Oliveira Silva and Edmundo Pessoa Lopes |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco |
3.222.710 |
|
| Corresponding Author |
Edmundo Pessoa Lopes, MD, PhD, Professor, Staff Physician, Programa de Pós-Graduação em Medicina Tropical, Centro de Ciências Médicas, Universidade Federal de Pernambuco, Estrada das Ubaias, 311, apto. 901-A, Recife 50670-901, Pernambuco, Brazil. epalopes@uol.com.br |
| Key Words |
Metabolomics; Portal hypertension; Schistosoma mansoni; Biomarkers; Neglected disease; Nuclear magnetic resonance |
| Core Tip |
In this study, we demonstrated a metabolic signatures and metabolic pathway disturbances that allowed to discriminate mild from significant periportal fibrosis in 41 patients with Schistosomiasis mansoni. Partial least squares-discriminant analysis (PLS-DA) and OPLS metabonomics models provided a clear separation between the groups. PLS-DA model presented accuracy, R2 and Q2 values equal to 0.85, 0.80 and 0.38, respectively, while OPLS model had R2 and Q2 values equal to 0.717 and 0.417, respectively. We also identified some metabolites responsible by discrimination which are associated with changes related to liver function and amino acids metabolism. |
| Publish Date |
2022-04-22 10:52 |
| Citation |
Rodrigues ML, da Luz TPSR, Pereira CLD, Batista AD, Domingues ALC, Silva RO, Lopes EP. Assessment of periportal fibrosis in Schistosomiasis mansoni patients by proton nuclear magnetic resonance-based metabonomics models. World J Hepatol 2022; 14(4): 719-728 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i4/719.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i4.719 |
