Publication Name	World Journal of Clinical Cases
Manuscript ID	73342
Country	China

Received	2021-11-19 00:14
Peer-Review Started	2021-11-19 00:17
To Make the First Decision
Return for Revision	2021-12-27 09:53
Revised	2022-01-10 09:08
Second Decision	2022-03-22 06:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-03-26 21:37
Articles in Press	2022-03-26 21:37
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-03-13 11:33
Typeset the Manuscript	2022-04-19 10:00
Publish the Manuscript Online	2022-05-24 14:32

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Case Report
Article Title	Clinical manifestations and gene analysis of Hutchinson-Gilford progeria syndrome: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Su-Li Zhang, Shuang-Zhu Lin, Yan-Qiu Zhou, Wan-Qi Wang, Jia-Yi Li, Cui Wang and Qi-Ming Pang
ORCID	Author(s) ORCID Number Su-Li Zhang http://orcid.org/0000-0001-5887-1026 Shuang-Zhu Lin http://orcid.org/0000-0001-5333-2138 Yan-Qiu Zhou http://orcid.org/0000-0001-6834-1723 Wan-Qi Wang http://orcid.org/0000-0002-8247-7616 Jia-Yi Li http://orcid.org/0000-0002-7729-4479 Cui Wang http://orcid.org/0000-0003-2723-5929 Qi-Ming Pang http://orcid.org/0000-0002-9501-1700
Funding Agency and Grant Number	Funding Agency Grant Number Hainan Province Clinical Medical Center (2021)75 Hainan Province Clinical Medical Center (2021)276
Corresponding Author	Qi-Ming Pang, MD, Associate Chief Physician, Department of Neuroscience, Hainan Women and Children's Medical Center, No. 15 Longkun Nan Lu, Haikou 570100, Hainan Province, China. 69704936@qq.com
Key Words	Hutchinson-Gilford progeria syndrome; LMNA; Children; Physiological function; Organ aging; Case report
Core Tip	The main clinical manifestations of Hutchinson-Gilford progeria syndrome (HGPS) in this 2-year-old boy were abnormal appearance, and growth and development lag behind children of the same age. DNA sequencing showed that there was a synonymous heterozygous mutation in the LMNA gene. This study provides a molecular basis for the etiological diagnosis of HGPS and genetic counseling for the family.
Publish Date	2022-05-24 14:32
Citation	Zhang SL, Lin SZ, Zhou YQ, Wang WQ, Li JY, Wang C, Pang QM. Clinical manifestations and gene analysis of Hutchinson-Gilford progeria syndrome: A case report. World J Clin Cases 2022; 10(15): 5018-5024
URL	https://www.wjgnet.com/2307-8960/full/v10/i15/5018.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i15.5018

Full Article (PDF)	WJCC-10-5018.pdf
Full Article (Word)	WJCC-10-5018.docx
CARE Checklist–2016	73342-CARE-Checklist–2016-revision.pdf
Manuscript File	73342_Auto_Edited-CCG-Wang TQ.docx
Answering Reviewers	73342-Answering reviewers.pdf
Audio Core Tip	73342-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	73342-Conflict-of-interest statement.pdf
Copyright License Agreement	73342-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	73342-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	73342-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	73342-Language certificate.pdf
Peer-review Report	73342-Peer-review(s).pdf
Scientific Misconduct Check	73342-Bing-Gao CC-2.png
Scientific Editor Work List	73342-Scientific editor work list.pdf