Publication Name	World Journal of Methodology
Manuscript ID	73515
Country	Greece

Received	2021-11-23 15:42
Peer-Review Started	2021-11-23 15:44
To Make the First Decision
Return for Revision	2022-02-08 10:22
Revised	2022-02-11 14:15
Second Decision	2022-03-18 06:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-03-27 06:29
Articles in Press	2022-03-27 06:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-03-15 10:39
Typeset the Manuscript	2022-04-15 02:38
Publish the Manuscript Online	2022-05-19 00:49

ISSN	2222-0682 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Clinical and Translational Research
Article Title	COVID-19 and thyroid disease: An infodemiological pilot study
Manuscript Source	Invited Manuscript
All Author List	Ioannis Ilias, Charalampos Milionis and Eftychia Koukkou
ORCID	Author(s) ORCID Number Ioannis Ilias http://orcid.org/0000-0001-5718-7441 Charalampos Milionis http://orcid.org/0000-0003-2442-3772 Eftychia Koukkou http://orcid.org/0000-0002-1433-3151
Funding Agency and Grant Number
Corresponding Author	Ioannis Ilias, MD, PhD, Consultant Physician-Scientist, Department of Endocrinology, Diabetes & Metabolism, Elena Venizelou Hospital, 2, Elena Venizelou Sq., Athens GR-11521, Greece. iiliasmd@yahoo.com
Key Words	Data collection; Epidemiology; Thyroid; Medical informatics; Methods; Trends
Core Tip	Google Trends searches for coronavirus disease 2019 (COVID-19)-associated terms have been linked to the epidemiology of COVID-19. In this study we aimed to assess worldwide COVID-19 cases per se vs COVID-19-associated Google Trends searches and thyroid-associated Google Trends searches for 92 wk. The study period was split in half and in each time period we performed cross-correlation analysis and mediation analysis. Significant cross correlation function factors for “COVID-19” and “severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)” were mostly found in the second time period, whereas COVID-19 cases per se were associated with “thyroid” searches in both time periods. In the second time period, which was characterized by the spread of SARS-CoV-2 delta variant, the effect of “COVID-19” searches on “thyroid” searches was significantly mediated by COVID-19 cases (P = 0.048). The observed time frame/sequence lends some credence to associations of COVID-19 cases per se with (apparent) thyroid disease.
Publish Date	2022-05-19 00:49
Citation	Ilias I, Milionis C, Koukkou E. COVID-19 and thyroid disease: An infodemiological pilot study. World J Methodol 2022; 12(3): 99-106
URL	https://www.wjgnet.com/2222-0682/full/v12/i3/99.htm
DOI	https://dx.doi.org/10.5662/wjm.v12.i3.99

Full Article (PDF)	WJM-12-99.pdf
Full Article (Word)	WJM-12-99.docx
Manuscript File	73515_Auto_Edited-LJH_WangTQ.docx
Answering Reviewers	73515-Answering reviewers.pdf
Audio Core Tip	73515-Audio core tip.mp3
Biostatistics Review Certificate	73515-Biostatistics statement.PDF
Clinical Trial Registration Statement	73515-Clinical trial registration statement.PDF
Conflict-of-Interest Disclosure Form	73515-Conflict-of-interest statement.pdf
Copyright License Agreement	73515-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	73515-Informed consent statement.PDF
Institutional Review Board Approval Form or Document	73515-Institutional review board statement.PDF
Non-Native Speakers of English Editing Certificate	73515-Language certificate.PDF
Supplementary Material	73515-Supplementary material.pdf
Peer-review Report	73515-Peer-review(s).pdf
Scientific Misconduct Check	73515-Bing-Liu JH-2.jpg
Scientific Misconduct Check	73515-CrossCheck.jpg
Scientific Editor Work List	73515-Scientific editor work list.pdf