| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism and therapeutic strategy of hepatic TM6SF2-deficient non-alcoholic fatty liver diseases via in vivo and in vitro experiments
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zu-Yin Li, Gang Wu, Qiu Chen, Zhi-Jie Zhou, Yu-Peng Wang, Guo-He Song, Chao Xiao, Xin Zhang, Gui-Long Deng, Rui-Tao Wang, Yu-Long Yang and Xiao-Liang Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81670514 |
| National Natural Science Foundation of China |
81702337 |
| Scientific Research Project of Shanghai Municipal Health Commission |
202040065 |
| Natural Science Foundation of Shanghai Scientific and Technological Project of Innovative Action |
20ZR1411900 |
|
| Corresponding Author |
Xiao-Liang Wang, PhD, Chief Doctor, Department of General Surgery, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, No. 1158 Park Road (E), Qingpu District, Shanghai 201700, China. xiaoliangwang2018@163.com |
| Key Words |
TM6SF2; Nonalcoholic fatty liver disease; Fatty acid metabolism; Treatment; MK-4074 |
| Core Tip |
In this study, we observed TM6SF2 overexpression in nonalcoholic fatty liver disease (NAFLD) cases. TM6SF2 overexpression can reduce hepatic lipid accumulation, suggesting a protective role for TM6SF2 in a high-fat diet. Meanwhile, there is an imbalance in the processes of uptake, synthesis, and intracellular expense of fatty acids in TM6SF2-deficient mouse models. Therefore, we propose possible therapeutic strategies for NAFLD caused by TM6SF2 deficiency. |
| Publish Date |
2022-07-04 12:30 |
| Citation |
Li ZY, Wu G, Qiu C, Zhou ZJ, Wang YP, Song GH, Xiao C, Zhang X, Deng GL, Wang RT, Yang YL, Wang XL. Mechanism and therapeutic strategy of hepatic TM6SF2-deficient non-alcoholic fatty liver diseases via in vivo and in vitro experiments. World J Gastroenterol 2022; 28(25): 2937-2954 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i25/2937.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i25.2937 |
