Publication Name	World Journal of Gastroenterology
Manuscript ID	75833
Country	China

Received	2022-03-24 07:46
Peer-Review Started	2022-03-24 07:49
To Make the First Decision
Return for Revision	2022-05-30 02:47
Revised	2022-06-08 07:50
Second Decision	2022-06-24 03:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-24 20:19
Articles in Press	2022-06-24 20:19
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-07-29 10:10
Typeset the Manuscript	2022-08-17 08:54
Publish the Manuscript Online	2022-08-26 07:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Study on the mechanism of Yinchenhao decoction in treating obstructive-jaundice-induced liver injury based on Nrf2 signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Jian Liu, Yan Xu, Shuai Chen, Cheng-Fei Hao, Jing Liang and Zhong-Lian Li
ORCID	Author(s) ORCID Number Jun-Jian Liu http://orcid.org/0000-0002-2754-8602 Yan Xu http://orcid.org/0000-0003-4350-8413 Shuai Chen http://orcid.org/0000-0003-0134-8300 Cheng-Fei Hao http://orcid.org/0000-0002-2491-411X Jing Liang http://orcid.org/0000-0001-8484-3547 Zhong-Lian Li http://orcid.org/0000-0001-5211-7612
Funding Agency and Grant Number	Funding Agency Grant Number the Scientific and Technological Project in Key Areas of Traditional Chinese Medicine of Tianjin Municipal Health and Health Committee, China 2019003 the Integrated Traditional Chinese and Western Medicine Project of Tianjin Municipal Health and Health Committee, China 2021042
Corresponding Author	Zhong-Lian Li, MD, PhD, Chief Doctor, Doctor, Professor, Surgeon, The Second Department of Hepatobiliary and Pancreatic Surgery, Tianjin Medical University NanKai Hospital, No. 6 Changjiang Street, Nankai District, Tianjin 300102, China. nkyylzl@163.com
Key Words	Yinchenhao decoction; Obstructive jaundice; Network pharmacology; Liver injury; Animal models; Oxidative stress
Core Tip	Obstructive Jaundice (OJ) may cause liver injury through various mechanisms. Traditional Chinese medicine has lots of advantages in treating OJ. The mechanism of Yinchenhao decoction (YCHD) for treating OJ-induced liver injury has made significant progress in recent years, but it is still unclear. We used the network pharmacology approach to predict the active components and putative targets of YCHD. We created the OJ rat models and through randomized controlled trials, concluded that YCHD could alleviate liver injury and oxidative damage, thereby promoting the translocation of NF-E2 related factor 2 (Nrf2) to the nucleus, and upregulating the Nrf2 signaling pathway.
Publish Date	2022-08-26 07:50
Citation	Liu JJ, Xu Y, Chen S, Hao CF, Liang J, Li ZL. The mechanism of Yinchenhao decoction in treating obstructive-jaundice-induced liver injury based on Nrf2 signaling pathway. World J Gastroenterol 2022; 28(32): 4635-4648
URL	https://www.wjgnet.com/1007-9327/full/v28/i32/4635.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i32.4635

Full Article (PDF)	WJG-28-4635.pdf
Full Article (Word)	WJG-28-4635.docx
The ARRIVE Guidelines	75833-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	75833_Auto_Edited-LM_Kerr C_Clear Copy.docx
Answering Reviewers	75833-Answering reviewers.pdf
Audio Core Tip	75833-Audio core tip.m4a
Biostatistics Review Certificate	75833-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	75833-Conflict-of-interest statement.pdf
Copyright License Agreement	75833-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	75833-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	75833-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	75833-Language certificate.pdf
Peer-review Report	75833-Peer-review(s).pdf
Scientific Editor Work List	75833-Scientific editor work list.pdf