Publication Name	World Journal of Clinical Cases
Manuscript ID	76061
Country	China

Received	2022-02-28 07:53
Peer-Review Started	2022-02-28 07:54
To Make the First Decision
Return for Revision	2022-05-11 09:55
Revised	2022-05-19 08:53
Second Decision	2022-06-17 03:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-17 23:20
Articles in Press	2022-06-17 23:20
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-06-13 02:07
Typeset the Manuscript	2022-07-11 00:19
Publish the Manuscript Online	2022-07-22 07:03

ISSN	2307-8960 (online)
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Prognostic role of multiple abnormal genes in non-small-cell lung cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Lu-Da Yan, Liu Yang, Na Li, Meng Wang, Yan-Hua Zhang, Wen Zhou, Zhi-Qiong Yu, Xiao-Chun Peng and Jun Cai
ORCID	Author(s) ORCID Number Lu-Da Yan http://orcid.org/0000-0003-3952-7523 Liu Yang http://orcid.org/0000-0001-7530-9588 Na Li http://orcid.org/0000-0002-0504-4753 Meng Wang http://orcid.org/0000-0001-7432-4436 Yan-Hua Zhang http://orcid.org/0000-0003-3468-903X Wen Zhou http://orcid.org/0000-0003-1416-9432 Zhi-Qiong Yu http://orcid.org/0000-0001-8644-6174 Xiao-Chun Peng http://orcid.org/0000-0001-9443-0439 Jun Cai http://orcid.org/0000-0002-2304-9734
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Hubei Province 2017CFB786 Hubei Province Health and Family Planning Scientific Research Project WJ2016Y10 Jingzhou Science and Technology Bureau Project 2017-93 College Students Innovative Entrepreneurial Training Program in Yangtze University 2019376
Corresponding Author	Jun Cai, MD, PhD, Chief Doctor, Department of Oncology, The First Affiliated Hospital of Yangtze University, No. 1 Nanhuan Road, Jingzhou 434023, Hubei Province, China. 529369023@qq.com
Key Words	Non-small-cell lung cancer; Gene mutation; Tyrosine kinase inhibitor; Overexpression; Next-generation sequencing; Epidermal growth factor receptor; KRAS
Core Tip	Non-small-cell lung cancer (NSCLC) has the highest morbidity and mortality rates among all malignant tumors. To explore the impact of simultaneous abnormalities of multiple genes on the prognosis and survival of patients. We used R packages to analyze gene expression data and clinical data downloaded from The Cancer Genome Atlas database. We also collected samples from 85 NSCLC patients from the First People's Hospital of Jingzhou City and retrospectively followed the patients for multivariate Cox regression analysis and survival analysis. Co-occurring mutation or overexpression of different genes has different effects on the overall survival and prognosis of patients. Combined with TKI treatment, the co-occurring mutation of some genes may have a synergistic effect on the survival and prognosis of NSCLC patients.
Publish Date	2022-07-22 07:03
Citation	Yan LD, Yang L, Li N, Wang M, Zhang YH, Zhou W, Yu ZQ, Peng XC, Cai J. Prognostic role of the abnormal multiple genes in non-small-cell lung cancer. World J Clin Cases 2022; 10(22): 7772-7784
URL	https://www.wjgnet.com/2307-8960/full/v10/i22/7772.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i22.7772

Full Article (PDF)	WJCC-10-7772.pdf
Full Article (Word)	WJCC-10-7772.docx
Manuscript File	76061_Auto_Edited_LM.docx
Answering Reviewers	76061-Answering reviewers.pdf
Audio Core Tip	76061-Audio core tip.aac
Biostatistics Review Certificate	76061-Biostatistics statement.pdf
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Copyright License Agreement	76061-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	76061-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	76061-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	76061-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	76061-Language certificate.pdf
Peer-review Report	76061-Peer-review(s).pdf
Scientific Misconduct Check	76061-Bing-Wang LL-2.png
Scientific Editor Work List	76061-Scientific editor work list.pdf