| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Serological profiling of Crohn’s disease and ulcerative colitis patients reveals anti-microbial antibody signatures
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mahasish Shome, Lusheng Song, Stacy Williams, Yunro Chung, Vel Murugan, Jin G Park, William Faubion, Shabana F Pasha, Jonathan A Leighton, Joshua LaBaer and Ji Qiu |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Ji Qiu, PhD, Research Assistant Professor, Virginia G. Piper Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, 1001 S McAllister Avenue, Tempe, AZ 85281, United States. ji.qiu@asu.edu |
| Key Words |
Inflammatory bowel disease; Anti-microbial antibody; Protein microarray; Crohn’s disease; Ulcerative colitis; Gut microbiome |
| Core Tip |
We performed the largest serological profiling of anti-microbial antibodies to date in using 100 Crohn’s disease (CD) and 100 ulcerative colitis (UC) patients. We identified novel anti-microbial antibodies with differential prevalence in inflammatory bowel disease (IBD) patients compared with healthy controls. There was minimal correlation between anti-microbial antibodies and our previously reported autoantibodies in CD patients. We combined novel anti-microbial antibodies to build biomarker panels distinguishing CD vs control, UC vs control and CD vs UC with an area under the curve of 0.81, 0.87, and 0.82, respectively. Subgroup analysis revealed that IBD patients with severe disease had the highest antibody prevalence. |
| Publish Date |
2022-08-10 08:23 |
| Citation |
Shome M, Song L, Williams S, Chung Y, Murugan V, Park JG, Faubion W, Pasha SF, Leighton J, LaBaer J, Qiu J. Serological profiling of Crohn’s disease and Ulcerative colitis patients reveals anti-microbial antibody signatures. World J Gastroenterol 2022; 28(30): 4089-4101 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i30/4089.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i30.4089 |
