Publication Name	World Journal of Clinical Cases
Manuscript ID	77662
Country	China

Received	2022-05-12 03:58
Peer-Review Started	2022-05-12 04:00
To Make the First Decision
Return for Revision	2022-06-16 02:54
Revised	2022-07-09 06:07
Second Decision	2022-09-15 03:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-09-16 11:11
Articles in Press	2022-09-16 11:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-09-07 12:57
Typeset the Manuscript	2022-09-22 00:38
Publish the Manuscript Online	2022-10-21 02:24

ISSN	2307-8960 (online)
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Category	Oncology
Manuscript Type	Case Report
Article Title	Hypophysitis induced by anti-programmed cell death protein 1 immunotherapy in non-small cell lung cancer: Three case reports
Manuscript Source	Unsolicited Manuscript
All Author List	Yun Zheng, Chen-Yu Zhu, Jing Lin, Wang-Shan Chen, Yu-Jie Wang, Hong-Ye Fu and Qiong Zhao
ORCID	Author(s) ORCID Number Yun Zheng http://orcid.org/0000-0003-0837-3656 Qiong Zhao http://orcid.org/0000-0001-7523-4432
Funding Agency and Grant Number
Corresponding Author	Qiong Zhao, PhD, Doctor, Zhejiang University School of Medicine, Zhejiang University, No. 866 Yuhangtang Road, Xihu District, Hangzhou 310030, Zhejiang Province, China. jade1972@126.com
Key Words	Programmed cell death protein 1; Immunotherapy; Hypophysitis; Lung cancer; Case reports
Core Tip	Hypophysitis induced by programmed cell death 1 protein (PD-1) inhibitor treatment in non-small cell lung cancer (NSCLC) was rarely reported. In this study, we report three patients with NSCLC who developed hypophysitis induced by PD-1 immune checkpoint inhibitor treatment. Our study suggested that unexpected fatigue, appetite decreases, nausea, vomiting, hoarse voice, bucking, and difficulty breathing were largely correlated with immune-related hypophysitis. We also found that the clinical prognosis of patients with hypophysitis was related to the dose of steroid therapy. This work provided a reference for the diagnosis and timely treatment of hypophysitis in the clinic.
Publish Date	2022-10-21 02:24
Citation	Zheng Y, Zhu CY, Lin J, Chen WS, Wang YJ, Fu HY, Zhao Q. Hypophysitis induced by anti-programmed cell death protein 1 immunotherapy in non-small cell lung cancer: Three case reports. World J Clin Cases 2022; 10(30): 11049-11058
URL	https://www.wjgnet.com/2307-8960/full/v10/i30/11049.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i30.11049

Full Article (PDF)	WJCC-10-11049.pdf
Full Article (Word)	WJCC-10-11049.docx
Manuscript File	77662_Auto_Edited-JJW-WangTQ-JLW.docx
Answering Reviewers	77662-Answering reviewers.pdf
Audio Core Tip	77662-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	77662-Conflict-of-interest statement.pdf
Copyright License Agreement	77662-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	77662-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	77662-Language certificate.pdf
Peer-review Report	77662-Peer-review(s).pdf
Scientific Misconduct Check	77662-Bing-Wang JJ-2.png
Scientific Editor Work List	77662-Scientific editor work list.pdf