| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical and Translational Research |
| Article Title |
Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Manon van der Vlugt, Beatriz Carvalho, Joelle Fliers, Nahid Montazeri, Christian Rausch, Esmée J Grobbee, Manon van Engeland, Manon C W Spaander, Gerrit A Meijer and Evelien Dekker |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Foundation of Population Screening Mid-West Netherlands, Amsterdam, The Netherlands (BoMW) |
|
| Foundation of Population Screening South-West Netherlands, Rotterdam, The Netherlands (BoZW) |
|
| Netherlands Comprehensive Cancer Organization (IKNL) |
|
| Netherlands Organization for Health Research and Development of the Dutch Ministry of Health (ZonMW) |
|
| PALGA, the Nationwide Network and Registry of Histo- and Cytopathology in the Netherlands |
|
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| Corresponding Author |
Manon van der Vlugt, MD, PhD, Doctor, Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Meibergdreef 9, Amsterdam 1105 AZ, Netherlands. m.vandervlugt@amsterdamumc.nl |
| Key Words |
Fecal immunochemical test-interval colorectal cancer; Mutation analysis; Colorectal cancer screening; Serrated pathway; Adenoma-carcinoma pathway |
| Core Tip |
Fecal immunochemical test (FIT) is effective in reducing colorectal cancer (CRC) but FIT testing is not perfect. FIT interval cancers, i.e. CRCs diagnosed after a negative FIT but before the next FIT invitation, still occur. Previous studies have shown that FIT sensitivity for sessile serrated lesions (SSLs) is low, but a correlation between the occurrence of FIT interval cancers and the serrated pathway has not been established. In our study, the serrated pathway-associated molecular features were more common in FIT-interval CRCs as compared to screen detected CRCs. This indicates that proximal serrated lesions may be overrepresented among FIT interval CRCs. The findings of this study can provide guidance on strategies to further improve stool-based CRC screening with incorporating biomarkers for SSLs, thereby reducing the number of screening interval CRCs. |
| Publish Date |
2022-11-15 10:19 |
| Citation |
Vlugt MVD, Carvalho B, Fliers J, Montazeri N, Rausch C, Grobbee EJ, Engeland MV, Spaander MC, Meijer GA, Dekker E. Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas. World J Gastrointest Oncol 2022; 14(11): 2195-2207 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i11/2195.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i11.2195 |
