| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
LINC01268 promotes epithelial-mesenchymal transition, invasion and metastasis of gastric cancer via the PI3K/Akt signaling pathway and targeting MARCKS
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ling-Han Tang, Peng-Cheng Ye, Lin Yao, Ya-Jun Luo, Wang Tan, Wan-Ping Xiang, Zi-Lin Liu, Ling Tan and Jiang-Wei Xiao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81070378, 81270561 |
| Natural Science Foundation of Sichuan Province, China |
2022NSFSC0050, 2023NSFSC1896 |
|
| Corresponding Author |
Jiang-Wei Xiao, MD, PhD, Doctor, Professor, Surgeon, Department of Gastrointestinal Surgery, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, No. 278, Baoguang Road, Xindu District, Chengdu 610000, Sichuan Province, China. xiaojiangwei2018@163.com |
| Key Words |
Gastric cancer; Long non-coding RNA; LINC01268; Myristoylated alanine rich protein kinase C substrate; Invasion; Metastasis |
| Core Tip |
Overexpression of LINC01268 was related to the prognosis of patients with gastric cancer (GC) and showed the value of auxiliary diagnosis. Overexpression of LINC01268 promoted the invasion and metastasis of GC cells. LINC01268 activated the PI3K/Akt signaling pathway and promoted epithelial-mesenchymal transition by targeting myristoylated alanine rich protein kinase C substrate and ultimately promoted the invasion and metastasis of GC. |
| Publish Date |
2023-08-10 14:08 |
| Citation |
Tang LH, Ye PC, Yao L, Luo YJ, Tan W, Xiang WP, Liu ZL, Tan L, Xiao JW. LINC01268 promotes epithelial-mesenchymal transition, invasion and metastasis of gastric cancer via the PI3K/Akt signaling pathway and targeting MARCKS. World J Gastrointest Oncol 2023; 15(8): 1366-1383 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i8/1366.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i8.1366 |
