| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Current overview of induced pluripotent stem cell-based blood-brain barrier-on-a-chip
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Arielly da Hora Alves, Mariana Penteado Nucci, Nicole Mastandrea Ennes do Valle, Juliana Morais Missina, Javier Bustamante Mamani, Gabriel Nery Albuquerque Rego, Olivia Furiama Metropolo Dias, Murilo Montenegro Garrigós, Fernando Anselmo de Oliveira and Lionel Fernel Gamarra |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CNPq |
308901/2020-7, 400856/2016-6 |
| FAPESP |
2019/21070-3, 2017/17868-4, 2016/21470-3 |
| SisNANO 2.0/MCTIC |
442539/2019-3 |
| National Institute of Science and Technology Complex Fluids, INCT-FCx |
|
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| Corresponding Author |
Lionel Fernel Gamarra, PhD, Academic Research, Professor, Research Associate, Teacher, N/A, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627/701, Morumbi, São Paulo 05529-060, São Paulo, Brazil. lgamarra@einstein.br |
| Key Words |
Induced pluripotent stem cells; Cell differentiation; Blood-brain barrier; Neurovascular unit; Organ-on-a-chip; Microfluidic device |
| Core Tip |
This systematic review provided a current perspective on the applicability of induced pluripotent stem cells within blood-brain barrier (BBB)-on-a-chip with high technology advances in commercial chips and promotion of an efficient human neurovascular unit, able to screen for drugs, mimic brain dysfunctions, such as stroke and Huntington’s disease, and suitable for future personalized therapeutic approaches. However, the composition and construction of the BBB models lack consensus in the literature. |
| Publish Date |
2023-06-26 14:09 |
| Citation |
Alves ADH, Nucci MP, Ennes do Valle NM, Missina JM, Mamani JB, Rego GNA, Dias OFM, Garrigós MM, de Oliveira FA, Gamarra LF. Current overview of induced pluripotent stem cell-based blood-brain barrier-on-a-chip. World J Stem Cells 2023; 15(6): 632-653 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i6/632.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i6.632 |
