Publication Name	World Journal of Stem Cells
Manuscript ID	85722
Country	China

Received	2023-05-12 01:56
Peer-Review Started	2023-05-12 01:59
To Make the First Decision
Return for Revision	2023-06-29 16:53
Revised	2023-07-23 15:50
Second Decision	2023-08-21 03:36
Accepted by Journal Editor-in-Chief	2023-08-23 17:20
Accepted by Company Editor-in-Chief	2023-09-07 15:49
Articles in Press	2023-09-07 15:49
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-08-18 08:27
Typeset the Manuscript	2023-09-20 00:23
Publish the Manuscript Online	2023-09-25 02:36

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Respiratory System
Manuscript Type	Basic Study
Article Title	Multiomics reveal human umbilical cord mesenchymal stem cells improving acute lung injury via the lung-gut axis
Manuscript Source	Unsolicited Manuscript
All Author List	Lu Lv, En-Hai Cui, Bin Wang, Li-Qin Li, Feng Hua, Hua-Dong Lu, Na Chen and Wen-Yan Chen
ORCID	Author(s) ORCID Number En-Hai Cui http://orcid.org/0000-0002-8808-8793
Funding Agency and Grant Number	Funding Agency Grant Number Key Research and Development Project of Science and Technology Department of Zhejiang Province 2019C03041
Corresponding Author	En-Hai Cui, BM BCh, Doctor, Department of Respiratory and Critical Care Medicine, Huzhou Central Hospital, Affiliated Huzhou Hospital, Zhejiang University School of Medicine, No. 1558 Third Ring North Road, Huzhou 313000, Zhejiang Province, China. kjkceh@126.com
Key Words	Acute lung injury; Human umbilical cord mesenchymal cells; Lipopolysaccharide; Microflora; Untargeted metabolomics; Toll-like receptor 4/nuclear factor kappa-B signaling pathway
Core Tip	The results of this study suggest that human umbilical cord mesenchymal cells (HUC-MSCs) inhibit the inflammatory cytokine expression levels in serum and the lung of mice with acute lung injury (ALI), which may be achieved by redefining the gut and lung microbiota. This study not only provides a scientific basis for the pathophysiological mechanisms and clinical application of HUC-MSCs, but it also provides new ideas for the development of therapeutic strategies for ALI.
Publish Date	2023-09-25 02:36
Citation	Lv L, Cui EH, Wang B, Li LQ, Hua F, Lu HD, Chen N, Chen WY. Correlation between gut and lung microbiota homeostases and human umbilical cord mesenchymal stem cells in acute lung injury. World J Stem Cells 2023; 15(9): 908-930
URL	https://www.wjgnet.com/1948-0210/full/v15/i9/908.htm
DOI	https://dx.doi.org/10.4252/wjsc.v15.i9.908

Full Article (PDF)	WJSC-15-908-with-cover.pdf
Full Article (Word)	WJSC-15-908.docx
Manuscript File	85722_Auto_Edited-LM.docx
Answering Reviewers	85722-Answering reviewers.pdf
Audio Core Tip	85722-Audio core tip.mp3
Biostatistics Review Certificate	85722-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	85722-Conflict-of-interest statement.pdf
Copyright License Agreement	85722-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	85722-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	85722-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	85722-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	85722-Language certificate.pdf
Supplementary Material	85722-Supplementary material.pdf
Peer-review Report	85722-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	85722-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	85722-Bing-Wang JJ-2.png
Scientific Editor Work List	85722-Scientific editor work list.pdf