Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	86056
Country	South Korea

Received	2023-06-08 01:14
Peer-Review Started	2023-06-08 01:17
To Make the First Decision
Return for Revision	2023-07-07 13:25
Revised	2023-07-13 09:00
Second Decision	2023-08-03 02:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-08-05 13:24
Articles in Press	2023-08-05 13:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-09-04 01:14
Publish the Manuscript Online	2023-09-22 12:52

ISSN	1948-9366 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Observational Study
Article Title	Comparative detection of syndecan-2 (SDC2) methylation in preoperative and postoperative stool DNA in patients with colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ji Hyeong Song, Tae Jeong Oh, Sungwhan An, Kyung Ha Lee, Ji Yeon Kim and Jin Soo Kim
ORCID	Author(s) ORCID Number Ji Hyeong Song http://orcid.org/0000-0002-7501-7259 Tae Jeong Oh http://orcid.org/0000-0001-6212-1949 Sungwhan An http://orcid.org/0000-0001-8781-4186 Kyung Ha Lee http://orcid.org/0000-0002-0035-9000 Ji Yeon Kim http://orcid.org/0000-0001-7964-5060 Jin Soo Kim http://orcid.org/0000-0002-3362-574X
Funding Agency and Grant Number	Funding Agency Grant Number Research Fund of Chungnam National University 2018-0626-01
Corresponding Author	Jin Soo Kim, MD, PhD, Assistant Professor, Surgery, Chungnam National University Sejong Hospital, 20, Bodeum 7-ro, Sejong-si, Republic of Korea, Sejong 30099, South Korea. jskim7562@gmail.com
Key Words	Biomarkers; DNA Methylation; Syndecan-2; Colorectal Cancer
Core Tip	This prospective study evaluated the detection of syndecan-2 (SDC2) methylation in preoperative and postoperative stool DNA samples of colorectal cancer (CRC) patients. The study demonstrated that the SDC2 methylation test showed high sensitivity (88.6%) for detecting CRC before surgery, indicating its potential as a non-invasive diagnostic tool. Postoperatively, the detection rate decreased to 19.7%, suggesting the normalization of SDC2 methylation after surgical resection. The study highlights the diagnostic value of SDC2 methylation in preoperative and postoperative stool samples, supporting its role as a non-invasive screening tool for CRC.
Publish Date	2023-09-22 12:52
Citation	Song JH, Oh TJ, An S, Lee KH, Kim JY, Kim JS. Comparative detection of syndecan-2 methylation in preoperative and postoperative stool DNA in patients with colorectal cancer. World J Gastrointest Surg 2023; 15(9): 2032-2041
URL	https://www.wjgnet.com/1948-9366/full/v15/i9/2032.htm
DOI	https://dx.doi.org/10.4240/wjgs.v15.i9.2032

Full Article (PDF)	WJGS-15-2032-with-cover.pdf
Full Article (Word)	WJGS-15-2032.docx
STROBE Statement	86056-STROBE-Statement-revision.pdf
Manuscript File	86056_Auto_Edited-LM.docx
Answering Reviewers	86056-Answering reviewers.pdf
Audio Core Tip	86056-Audio core tip.m4a
Biostatistics Review Certificate	86056-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	86056-Conflict-of-interest statement.pdf
Copyright License Agreement	86056-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	86056-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	86056-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	86056-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	86056-Language certificate.pdf
Peer-review Report	86056-Peer-review(s).pdf
Scientific Editor Work List	86056-Scientific editor work list.pdf