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Articles Published Processes
1/23/2024 4:13:00 AM | Browse: 85 | Download: 142
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Received |
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2023-08-30 02:12 |
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Peer-Review Started |
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2023-08-30 02:14 |
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To Make the First Decision |
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Return for Revision |
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2023-11-21 01:17 |
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Revised |
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2023-12-02 15:22 |
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Second Decision |
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2023-12-18 03:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-12-25 06:49 |
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Articles in Press |
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2023-12-25 06:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2023-12-30 07:59 |
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Typeset the Manuscript |
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2024-01-13 12:44 |
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Publish the Manuscript Online |
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2024-01-23 04:13 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Li, William Lee, Zhen-Gang Zhao, Yi Liu, Hao Cui and Hao-Yu Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Tianjin Key Medical Discipline Construction Project |
TJYXZDXK-034A |
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| Corresponding Author |
Yan Li, MD, Chief Physician, Department of Gastroenterology, Tianjin Third Central Hospital, 83 Jintang Road, Hedong District, Tianjin 300170, China. li13821177880@126.com |
| Key Words |
Hepatocellular carcinoma; Fatty acid binding protein; Novel target; Amplification; Correlated expression |
| Core Tip |
Several recent studies reported that fatty acid binding proteins (FABPs) contribute to reprogrammed lipid metabolism and cancer progression; however, how these FABPs are dysregulated in cancer, especially in hepatocellular carcinoma (HCC), has not been carefully addressed. We discovered that a FABP gene cluster including FABP5 are frequently amplified in cancer. FABP5 is significantly upregulated in HCC and its high expression correlates well with worse patient outcomes, enrichment of top enriched cancer hallmarks involved in cell cycle progression, and two oncogenes PLK1 and BIRC5 in HCC. FABP5 inhibition impaired the cell viability of FABP5high HCC cells. Our data supported that FABP5 is a novel therapeutic target for treating HCC. |
| Publish Date |
2024-01-23 04:13 |
| Citation |
Li Y, Lee W, Zhao ZG, Liu Y, Cui H, Wang HY. Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma. World J Clin Oncol 2024; 15(1): 130-144 |
| URL |
https://www.wjgnet.com/2218-4333/full/v15/i1/130.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v15.i1.130 |
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