Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	87164
Country	Portugal

Received	2023-07-27 21:25
Peer-Review Started	2023-07-27 21:27
To Make the First Decision
Return for Revision	2023-09-05 20:17
Revised	2023-09-28 11:43
Second Decision	2023-11-01 07:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-11-08 18:46
Articles in Press	2023-11-08 18:46
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-11-13 11:05
Typeset the Manuscript	2024-01-04 02:17
Publish the Manuscript Online	2024-01-11 06:17

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Case Report
Article Title	Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	João Gramaça, Isabel Gomes Fernandes, Carolina Trabulo, Joana Gonçalves, Rita Gameiro dos Santos, Adriano Baptista and Idília Pina
ORCID	Author(s) ORCID Number João Gramaça http://orcid.org/0000-0001-6968-0436
Funding Agency and Grant Number
Corresponding Author	João Gramaça, MD, Doctor, Centro Hospitalar Barreiro Montijo, Centro Hospitalar Barreiro Montijo, Avenida Movimento das Forças Armadas, Barreiro 2830-003 , Setúbal, Portugal. jpgramaca@gmail.com
Key Words	Metastatic colorectal cancer; Rat sarcoma virus mutational status; Liquid biopsy; Rat sarcoma virus wild type; Neo-rat sarcoma virus wild type; Anti-epidermal growth factor receptor therapy; Case report
Core Tip	In patients with metastatic colorectal cancer (mCRC), the treatment options are limited and proved to be affected by rat sarcoma virus (RAS) mutational status. This manuscript describes a series of 11 RAS-mutated mCRC patients who were treated with a combination of chemotherapy and bevacizumab at first line. Four patients became neo-RAS wt after first or second line treatment and were treated with cetuximab, with advantages in terms of survival and disease progression.
Publish Date	2024-01-11 06:17
Citation	Gramaça J, Fernandes IG, Trabulo C, Gonçalves J, dos Santos RG, Baptista A, Pina I. Emerging role of liquid biopsy in rat sarcoma virus mutated metastatic colorectal cancer: A case report. World J Gastrointest Oncol 2024; 16(1): 234-243
URL	https://www.wjgnet.com/1948-5204/full/v16/i1/234.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i1.234

Full Article (PDF)	WJGO-16-234-with-cover.pdf
Full Article (Word)	WJGO-16-234.docx
CARE Checklist–2016	87164-CARE Checklist (2016) .pdf
Manuscript File	87164_Auto_Edited-LM-Language editing-Webster J.docx
Answering Reviewers	87164-Answering reviewers.pdf
Audio Core Tip	87164-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	87164-Conflict-of-interest statement.pdf
Copyright License Agreement	87164-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	87164-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	87164-Language certificate.pdf
Peer-review Report	87164-Peer-review(s).pdf
Scientific Misconduct Check	87164-Bing-Qu XL-2.jpg
Scientific Editor Work List	87164-Scientific editor work list.pdf