| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Metabolomics in chronic hepatitis C: Decoding fibrosis grading and underlying pathways
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Adriana Camargo Ferrasi, Samara Vitória Granja Lima, Aline Faria Galvani, Jeany Delafiori, Flavia Luísa Dias-Audibert, Rodrigo Ramos Catharino, Giovanni Faria Silva, Roberta Rodrigues Praxedes, Driele Bretones Santos, Dayane Trevisan de Macedo Almeida and Estela Oliveira Lima |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| São Paulo Research Foundation |
No. 2021/04753-0 |
|
| Corresponding Author |
Adriana Camargo Ferrasi, PhD, Professor, Department of Internal Medicine, Sao Paulo State University, s/n, Professor Armando Alves Avenue, Botucatu 18618-686, Brazil. adriana.ferrasi@unesp.br |
| Key Words |
Chronic Hepatitis C; Fibrosis; Metabolome; Biomarkers; Plasma; Liquid Biopsy |
| Core Tip |
Chronic Hepatitis C affects 71 million people globally and leads to liver fibrosis, cirrhosis, cancer, and death. The accurate staging of fibrosis is crucial for treatment decisions and outcome prediction. Blood markers are a relevant source of information, and various molecular biomarkers have been investigated to characterize liver fibrosis. We analyzed plasma metabolites by mass spectrometry in 50 healthy participants, and in 46 patients with hepatitis C and classified them into fibrosis grades F1-F4. Six differential metabolites were identified in each grade of fibrosis; their biochemical pathways were analyzed and suggests molecular mechanisms involved in the disease. |
| Publish Date |
2023-11-24 06:10 |
| Citation |
Ferrasi AC, Lima SVG, Galvani AF, Delafiori J, Dias-Audibert FL, Catharino RR, Silva GF, Praxedes RR, Santos DB, Almeida DTM, Lima EO. Metabolomics in chronic hepatitis C: Decoding fibrosis grading and underlying pathways. World J Hepatol 2023; 15(11): 1237-1249 |
| URL |
https://www.wjgnet.com/1948-5182/full/v15/i11/1237.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v15.i11.1237 |
