Publication Name	World Journal of Gastroenterology
Manuscript ID	87880
Country	China

Received	2023-08-31 13:55
Peer-Review Started	2023-08-31 13:58
To Make the First Decision
Return for Revision	2023-10-29 04:22
Revised	2023-11-08 07:45
Second Decision	2023-12-11 07:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-12-18 06:05
Articles in Press	2023-12-18 06:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-01-12 02:49
Publish the Manuscript Online	2024-01-18 09:58

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis
Manuscript Source	Unsolicited Manuscript
All Author List	Qing Gu, Huan Xia, Yue-Qiong Song, Jun Duan, Yun Chen, You Zhang, He-Ping Chen and Li Zhang
ORCID	Author(s) ORCID Number He-Ping Chen http://orcid.org/0009-0000-8860-5247 Li Zhang http://orcid.org/0009-0005-5978-5310
Funding Agency and Grant Number	Funding Agency Grant Number The Key Research and Development Projects of Sichuan Science and Technology Department 2023YFS0285 Natural Science Foundation Project of Sichuan Science and Technology Department 2023NSFSC0613
Corresponding Author	Li Zhang, PhD, Doctor, Professor, Department of Elderly Digestive, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology, 32 West Section 2, Yihuan Road, Chengdu 610072, Sichuan Province, China. 1262867096@qq.com
Key Words	Ulcerative colitis; SLC6A1; NLRP3; Pyroptosis; Inflammasome
Core Tip	Ulcerative colitis (UC) is an inflammatory condition associated with frequent relapse and recurrence. Dysregulation of intestinal epithelial cells (IECs) and mucosal barrier impairment contribute to sustained inflammation in UC. Hence, an in-depth exploration of the triggers and mechanisms of IEC death could result in efficacious therapeutic options for UC patients. Here, we demonstrated the close involvement of SLC6A14 in promoting pyroptosis in the context of UC by upregulating NLRP3 expression. These findings indicate the potential of targeting SLC6A14/NLRP3 axis-mediated pyroptosis as a promising therapeutic strategy for treating UC. Our research provides valuable insights into the mechanisms driving UC pathogenesis and offers a possible direction for developing innovative treatments to alleviate the impact of this chronic inflammatory disorder.
Publish Date	2024-01-18 09:58
Citation	Gu Q, Xia H, Song YQ, Duan J, Chen Y, Zhang Y, Chen HP, Zhang L. SLC6A14 promotes ulcerative colitis progression by facilitating NLRP3 inflammasome-mediated pyroptosis. World J Gastroenterol 2024; 30(3): 252-267
URL	https://www.wjgnet.com/1007-9327/full/v30/i3/252.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i3.252

Full Article (PDF)	WJG-30-252-with-cover.pdf
Full Article (Word)	WJG-30-252.docx
The ARRIVE Guidelines	87880-The ARRIVE guidelines.pdf
Manuscript File	87880_Auto_Edited-YJP.docx
Answering Reviewers	87880-Answering reviewers.pdf
Audio Core Tip	87880-Audio core tip.mp3
Biostatistics Review Certificate	87880-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	87880-Conflict-of-interest statement.pdf
Copyright License Agreement	87880-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	87880-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	87880-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	87880-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	87880-Language certificate.pdf
Supplementary Material	87880-Supplementary material.pdf
Peer-review Report	87880-Peer-review(s).pdf
Scientific Misconduct Check	87880-Bing-Gao CC-2.png
Scientific Editor Work List	87880-Scientific editor work list.pdf