| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ren-Yong Wang, Jia-Ling Yang, Ning Xu, Jia Xu, Shao-Hua Yang, Dao-Ming Liang, Jin-Ze Li and Hong Zhu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81460132 |
| Yunnan Packnrovincial Department of Science, Technology-Kunming Medical University Applied Basic Research Joint Special Fund Project |
2018FE001 (-224) |
|
| Corresponding Author |
Hong Zhu, PhD, Professor, Second Affiliated Hospital of Kunming Medical University, Second Affiliated Hospital of Kunming Medical University, No. 374 Dian-Mian Avenue, Wuhua District, Kunming 650106, Yunnan Province, China. zhuhong@kmmu.edu.cn |
| Key Words |
Hepatocellular carcinoma; Lipid metabolism; Immune microenvironment; Prognostic markers; Metabolic reprogramming |
| Core Tip |
In the current study, we investigated the functions of lipid metabolism-related long noncoding RNAs (LMR-lncRNAs) in assessing and forecasting the prognosis of patients with hepatocellular carcinoma (HCC), and established an accurate and reliable lipid metabolism-related risk score model for prediction. In particular, we focused on a novel LMR-lncRNA, RP11-817I4.1, which proved its important regulatory role in HCC lipid metabolism and tumor progression and showed therapeutic potential. Our findings will be extremely beneficial in understanding the probable molecular biological processes of HCC and discovering novel prognostic indicators and molecular targets. |
| Publish Date |
2024-02-26 13:28 |
| Citation |
Wang RY, Yang JL, Xu N, Xu J, Yang SH, Liang DM, Li JZ, Zhu H. Lipid metabolism-related lncRNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma. World J Gastroenterol 2024; 30(8): 919-942 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i8/919.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i8.919 |
