| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Lean body mass index is a marker of advanced tumor features in patients with hepatocellular carcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Andrew Scott deLemos, Jing Zhao, Milin Patel, Banks Kooken, Karan Mathur, Hieu Minh Nguyen, Areej Mazhar, Maggie McCarter, Heather Burney, Carla Kettler, Naga Chalasani and Samer Gawrieh |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| in part David W Crabb Professorship Endowment at Indiana University School of Medicine and an intramural grant from the Atrium Health Center for Outcomes Research and Evaluation (CORE) (to Andrew Scott deLemos). |
|
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| Corresponding Author |
Andrew Scott deLemos, MD, Associate Professor, Department of Medicine, Atrium Health, 1025 Morehead Medical Drive, Suite 600, Charlotte, NC 28204, United States. andrew.delemos@atriumhealth.org |
| Key Words |
Hepatocellular carcinoma; Cirrhosis; Obesity; Body mass index class; Sarcopenia; Chronic hepatitis C |
| Core Tip |
This study explores the impact of different body mass index (BMI) strata on patient survival following the diagnosis of hepatocellular carcinoma (HCC). We stratified patients with cirrhosis by lean (BMI < 25 kg/m2), overweight BMI (25-29.9 kg/m2), and obese (BMI ≥ 30 kg/m2) categories, and analyzed patient and tumor characteristics. Lean patients with HCC presented with significantly larger tumors as well as more advanced tumors. Survival was significantly reduced in lean HCC patients in the overall cohort but was restricted to those patients outside Milan criteria following sub-group analysis. We included a survival analysis by BMI class according to the three most common chronic liver diseases: Chronic hepatitis C, alcoholic liver disease, and nonalcoholic fatty liver disease. Lastly, we found no significant difference in survival comparing the three BMI classes from our sub-group of 286 patients with HCC but without cirrhosis. |
| Publish Date |
2024-03-27 13:28 |
| Citation |
deLemos AS, Zhao J, Patel M, Kooken B, Mathur K, Nguyen HM, Mazhar A, McCarter M, Burney H, Kettler C, Chalasani N, Gawrieh S. Lean body mass index is a marker of advanced tumor features in patients with hepatocellular carcinoma. World J Hepatol 2024; 16 (3): 393-404 |
| URL |
https://www.wjgnet.com/1948-5182/full/v16/i3/393.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v16.i3.393 |
