Publication Name	World Journal of Gastroenterology
Manuscript ID	90034
Country	United States

Received	2023-11-21 05:11
Peer-Review Started	2023-11-21 05:13
To Make the First Decision
Return for Revision	2023-12-25 05:29
Revised	2024-01-10 04:55
Second Decision	2024-02-28 02:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-02-28 05:53
Articles in Press	2024-02-28 05:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-03-05 01:00
Publish the Manuscript Online	2024-03-21 11:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	MicroRNAs in hepatocellular carcinoma treatment: Charting the path forward
Manuscript Source	Invited Manuscript
All Author List	Hong T Lin, Antonio F Alvarez Castaneda, Somashekar G Krishna and Khalid Mumtaz
ORCID	Author(s) ORCID Number Hong T Lin http://orcid.org/0000-0002-1888-2860 Somashekar G Krishna http://orcid.org/0000-0001-5748-7890 Khalid Mumtaz http://orcid.org/0000-0001-7868-6514
Funding Agency and Grant Number
Corresponding Author	Khalid Mumtaz, MBBS, Associate Professor, Doctor, Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, The Ohio State University Wexner Medical Center, 395 W 12th Ave, Columbus, OH 43210, United States. khalid.mumtaz@osumc.edu
Key Words	Hepatocellular carcinoma; Tumor microenvironment; MicroRNA; Mesenchymal stem cell; Exosome
Core Tip	MicroRNAs (miRNAs) constitute a family of molecules with dual roles in both the development and prevention of cirrhosis and hepatocellular carcinoma (HCC). Depending on the type of miRNA and the target of interest, they have the potential to promote or inhibit angiogenesis, facilitate or inhibit immune invasion, and enable or halt cell cycle progression amongst other effects. When paired with safe and effective delivery vehicles, specific miRNAs show promise as targeted therapies for treating HCC. Nonetheless, owing to the intricate interactions within in vivo systems and limitations of current retrospective studies, further research is imperative to ensure the safety and efficacy of miRNA in HCC therapy.
Publish Date	2024-03-21 11:37
Citation	Lin HT, Castaneda AFA, Krishna SG, Mumtaz K. MicroRNAs in hepatocellular carcinoma treatment: Charting the path forward. World J Gastroenterol 2024; 30(11): 1470-1474
URL	https://www.wjgnet.com/1007-9327/full/v30/i11/1470.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i11.1470

Full Article (PDF)	WJG-30-1470-with-cover.pdf
Manuscript File	90034_Auto_Edited-YJP.docx
Answering Reviewers	90034-Answering reviewers.pdf
Audio Core Tip	90034-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	90034-Conflict-of-interest statement.pdf
Copyright License Agreement	90034-Copyright license agreement.pdf
Peer-review Report	90034-Peer-review(s).pdf
Scientific Misconduct Check	90034-Bing-Wang JJ-2.png
Scientific Editor Work List	90034-Scientific editor work list.pdf