| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Retrospective Study |
| Article Title |
Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Brendha Cação Coimbra, Marina Alessandra Pereira, Leonardo Cardili, Venancio Avancini Ferreira Alves, Evandro Sobroza de Mello, Ulysses Ribeiro Jr and Marcus Fernando Kodama Pertille Ramos |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP agency) |
2020/02880-1 |
|
| Corresponding Author |
Marina Alessandra Pereira, MSc, PhD, Research Scientist, Department of Gastroenterology, Instituto do Cancer, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Faculdade de Medicina, Universidade de São Paulo, Av Dr Arnaldo, 251, São Paulo 01246000, Brazil. marina.pereira@hc.fm.usp.br |
| Key Words |
Gastric cancer; Lymph node; Programmed death ligand 1; Stomach neoplasms; Immunohistochemistry; Metastasis |
| Core Tip |
This is a retrospective study comparing programmed death-ligand 1 (PD-L1) expression in primary tumors (PTs) and matched lymph node metastases (LNM) of gastric cancer patients who underwent D2-gastrectomy. Among 284 patients, 24 were PD-L1 positivity in PT and had LNM. Among patients with PD-L1 positive in PT, 54.2% were also positive for PD-L1 in LNM. Considering the PD-L1 negative patients in PT, 9.1% of had PD-L1 positive in LNM. Accordingly, the intra-patient heterogeneity in PD-L1 expression between the PT and matched LNM found in our study may emphasize the importance of considering the site of tumor sample examined when selecting patients for immunotherapy. |
| Publish Date |
2024-03-12 10:04 |
| Citation |
Coimbra BC, Pereira MA, Cardili L, Alves VAF, Mello ES, Ribeiro Jr U, Ramos MFKP. Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma. World J Gastrointest Oncol 2024; 16(3): 883-893 |
| URL |
https://www.wjgnet.com/1948-5204/full/v16/i3/883.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v16.i3.883 |
