Publication Name	World Journal of Stem Cells
Manuscript ID	92114
Country	China

Received	2024-01-15 16:10
Peer-Review Started	2024-01-15 16:10
To Make the First Decision
Return for Revision	2024-01-29 21:00
Revised	2024-02-11 09:35
Second Decision	2024-03-14 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-14 04:36
Articles in Press	2024-03-14 04:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-17 13:09
Publish the Manuscript Online	2024-04-25 05:24

ISSN	1948-0210 (online)
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Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction
Manuscript Source	Unsolicited Manuscript
All Author List	Cheng-Jin Ai, Ling-Juan Chen, Li-Xuan Guo, Ya-Ping Wang and Zi-Yi Zhao
ORCID	Author(s) ORCID Number Zi-Yi Zhao http://orcid.org/0000-0003-1871-5197
Funding Agency and Grant Number
Corresponding Author	Zi-Yi Zhao, PhD, Professor, Central Laboratory, Hospital of Chengdu University of Traditional Chinese Medicine, Shi-er-qiao Road, Chengdu 641000, Sichuan Province, China. zhaoziyi@cdutcm.edu.cn
Key Words	Leukemia stem cells; Gossypol acetic acid; Reactive oxygen species; Mitochondrial dysfunction; Interleukin 6/janus kinase 1/signal transducer and activator of transcription 3 signaling
Core Tip	Gossypol acetic acid (GAA) inhibited janus kinase 1/signal transducer and activator of transcription 3 signaling activated by interleukin 6 in leukemia stem cells (LSCs). GAA sensitizes to chemoagent, including cytarabine, Dexamethasone and L-Asparaginase in LSCs. GAA decreased leucine-rich pentatricopeptide repeat-containing protein and subsequent downregulated forkhead box M1, which are critical and necessary for stemness of LSCs. GAA induces mitochondrial dysfunction via inducing reactive oxygen species accumulation. GAA might eliminate the effects of inflammatory environment on LSCs.
Publish Date	2024-04-25 05:24
Citation	Ai CJ, Chen LJ, Guo LX, Wang YP, Zhao ZY. Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction. World J Stem Cells 2024; 16(4): 444-458
URL	https://www.wjgnet.com/1948-0210/full/v16/i4/444.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i4.444

Full Article (PDF)	WJSC-16-444-with-cover.pdf
Manuscript File	92114_Auto_Edited-YJP.docx
Answering Reviewers	92114-Answering reviewers.pdf
Audio Core Tip	92114-Audio core tip.m4a
Biostatistics Review Certificate	92114-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	92114-Conflict-of-interest statement.pdf
Copyright License Agreement	92114-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	92114-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	92114-Language certificate.pdf
Peer-review Report	92114-Peer-review(s).pdf
Scientific Misconduct Check	92114-Bing-Wang JJ-2.png
Scientific Editor Work List	92114-Scientific editor work list.pdf