Publication Name	World Journal of Transplantation
Manuscript ID	58666
Country	Australia

Received	2020-08-02 07:53
Peer-Review Started	2020-08-02 07:54
To Make the First Decision
Return for Revision	2020-09-17 16:50
Revised	2020-10-09 03:31
Second Decision	2020-10-30 10:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-10-30 22:40
Articles in Press	2020-10-30 22:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-11-17 11:57
Publish the Manuscript Online	2020-11-23 10:54

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Donor-specific cell-free DNA as a biomarker in liver transplantation: A review
Manuscript Source	Invited Manuscript
All Author List	Tess McClure, Su Kah Goh, Daniel Cox, Vijayaragavan Muralidharan, Alexander Dobrovic and Adam G Testro
Funding Agency and Grant Number	Funding Agency Grant Number The University of Melbourne, Parkville 3000, VIC, Australia
Corresponding Author	Tess McClure, FRACP, MBBS, Doctor, Research Fellow, Department of Liver Transplant Unit, Austin Health, 145 Studley Rd, Heidelberg 3084, VIC, Australia. tess.mcclure@austin.org.au
Key Words	Biomarkers; Precision medicine; Donor-specific cell-free DNA; Liver transplantation; Rejection; Review
Core Tip	Donor-specific cell-free DNA is a biomarker with promising clinical utility in liver transplantation. It demonstrates stereotypic dynamics in states of graft health, and is an early and accurate marker of acute rejection. This has been demonstrated in other solid-organ transplantations, where certain assays have progressed to commercialisation. Further studies examining donor-specific cell free DNA in liver transplantation, such as a randomised controlled trial or in combination with other assays, will assist with its translation into clinical practice. Ultimately, this emerging biomarker will need to be used in an integrated manner by experienced clinicians so as to improve patient outcomes.
Publish Date	2020-11-23 10:54
Citation	McClure T, Goh SK, Cox D, Muralidharan V, Dobrovic A, Testro AG. Donor-specific cell-free DNA as a biomarker in liver transplantation: A review. World J Transplant 2020; 10(11): 307-319
URL	https://www.wjgnet.com/2220-3230/full/v10/i11/307.htm
DOI	https://dx.doi.org/10.5500/wjt.v10.i11.307

Full Article (PDF)	WJT-10-307.pdf
Full Article (Word)	WJT-10-307.docx
Manuscript File	58666_Auto_Edited.docx
Answering Reviewers	58666-Answering reviewers.pdf
Audio Core Tip	58666-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	58666-Conflict-of-interest statement.pdf
Copyright License Agreement	58666-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	58666-Grant application form(s).pdf
Peer-review Report	58666-Peer-review(s).pdf
Scientific Misconduct Check	58666-Bing-Fan JR-2.png
Scientific Misconduct Check	58666-Bing-Ma YJ-1.jpg
Scientific Misconduct Check	58666-Scientific misconduct check.pdf
Scientific Editor Work List	58666-Scientific editor work list.pdf