Publication Name	World Journal of Pharmacology
Manuscript ID	78795
Country	Malaysia

Received	2022-07-15 01:51
Peer-Review Started	2022-07-15 01:55
To Make the First Decision
Return for Revision	2022-09-26 10:11
Revised	2022-10-04 09:41
Second Decision	2022-11-14 03:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-11-23 23:51
Articles in Press	2022-11-23 23:51
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-11-10 01:04
Typeset the Manuscript	2022-11-26 10:50
Publish the Manuscript Online	2022-11-28 09:47

ISSN	2220-3192 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pharmacology & Pharmacy
Manuscript Type	Review
Article Title	Controversial usages of kratom (Mitragyna speciosa): For good or for evil
Manuscript Source	Invited Manuscript
All Author List	Murtadha Basheer, Rana Khudhair Jasim and Gam Lay Harn
Funding Agency and Grant Number	Funding Agency Grant Number Ministry of Higher Education Malaysia for the Fundamental Research Grant Scheme FRGS/1/2020/STG02/USM/01/1
Corresponding Author	Gam Lay Harn, PhD, Professor, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 USM, Minden 11800, Penang, Malaysia. layharn@usm.my
Key Words	Kratom; Opioid; Pharmacological actions; Toxicity; Addiction; Herbal plant
Core Tip	Traditionally, people discovered kratom (Mitragyna speciose) possessed stimulating effect that relieved tiredness after long day labor. Long term or regular consumption of kratom lead to addiction because the main alkaloid of kratom binds to opioid receptors and exerts euphoric effect. Due to this reason, kratom has been listed as regulated substance in many countries. Despite of the euphoric effect of kratom, the beneficial values of kratom to human health is indisputable. Therefore, a complete banning of kratom may cause a loss to pharmaceutical industry. Rather, a controlled or selective usage of kratom will be a better choice.
Publish Date	2022-11-28 09:47
Citation	Basheer M, Khudhair Jasim R, Gam LH. Controversial usages of kratom (Mitragyna speciosa): For good or for evil. World J Pharmacol 2022; 11(3): 16-26
URL	https://www.wjgnet.com/2220-3192/full/v11/i3/16.htm
DOI	https://dx.doi.org/10.5497/wjp.v11.i3.16

Full Article (PDF)	WJP-11-16.pdf
Full Article (Word)	WJP-11-16.docx
Manuscript File	78795_Auto_Edited-LM.docx
Answering Reviewers	78795-Answering reviewers.pdf
Audio Core Tip	78795-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	78795-Conflict-of-interest statement.pdf
Copyright License Agreement	78795-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	78795-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	78795-Language certificate.pdf
Peer-review Report	78795-Peer-review(s).pdf
Scientific Misconduct Check	78795-Bing-Fan JR-2.png
Scientific Editor Work List	78795-Scientific editor work list.pdf