Publication Name	World Journal of Stem Cells
Manuscript ID	82656
Country	China

Received	2022-12-26 13:10
Peer-Review Started	2022-12-26 13:12
To Make the First Decision
Return for Revision	2023-01-06 17:50
Revised	2023-01-19 04:25
Second Decision	2023-02-24 04:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2023-02-28 02:52
Articles in Press	2023-02-28 02:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2023-03-20 01:52
Publish the Manuscript Online	2023-03-23 08:29

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Neurosciences
Manuscript Type	Review
Article Title	Immunomodulation: The next target of mesenchymal stem cell-derived exosomes in the context of ischemic stroke
Manuscript Source	Invited Manuscript
All Author List	Xiao-Qian Shan, Yong-Yin Luo, Jun Chang, Jing-Jing Song, Nan Hao and Lan Zhao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82074533
Corresponding Author	Lan Zhao, PhD, Research Fellow, NA, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, No. 88 Chang Ling Road, Xi Qing District, Tianjin 300381, China. lanzhao69@163.com
Key Words	Mesenchymal stem cells; Exosomes; Ischemic stroke; Immunomodulation; Inflammation; Exosome therapy
Core Tip	Mesenchymal stem cell-derived exosomes (MSC-Exos) are an emerging strategy for treating ischemic stroke (IS) and have demonstrated certain achievements in animal studies. Here, we review and discuss the mechanisms of MSC-Exos in treating IS through immunomodulation, the current responses to the clinical limitations of MSC-Exos therapy, and the issues that need to be addressed in future MSC-Exos research.
Publish Date	2023-03-23 08:29
Citation	Shan XQ, Luo YY, Chang J, Song JJ, Hao N, Zhao L. Immunomodulation: The next target of mesenchymal stem cell-derived exosomes in the context of ischemic stroke. World J Stem Cells 2023; 15(3): 52-70
URL	https://www.wjgnet.com/1948-0210/full/v15/i3/52.htm
DOI	https://dx.doi.org/10.4252/wjsc.v15.i3.52

Full Article (PDF)	WJSC-15-52.pdf
Full Article (Word)	WJSC-15-52.docx
Manuscript File	82656_Auto_Edited-LM.docx
Answering Reviewers	82656-Answering reviewers.pdf
Audio Core Tip	82656-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	82656-Conflict-of-interest statement.pdf
Copyright License Agreement	82656-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	82656-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	82656-Language certificate.pdf
Peer-review Report	82656-Peer-review(s).pdf
Scientific Misconduct Check	82656-Bing-Fan JR-2.png
Scientific Editor Work List	82656-Scientific editor work list.pdf