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12/15/2014 12:28:00 PM | Browse: 708 | Download: 1514
Publication Name World Journal of Translational Medicine
Manuscript ID 12821
Country/Territory Italy
Received
2014-07-27 16:41
Peer-Review Started
2014-07-27 23:24
To Make the First Decision
2014-09-16 10:59
Return for Revision
2014-09-16 17:13
Revised
2014-09-25 22:34
Second Decision
2014-11-03 16:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-11-03 17:11
Articles in Press
2014-11-03 17:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-11-25 11:16
Publish the Manuscript Online
2014-12-13 17:57
ISSN 2220-6132 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology & Metabolism
Manuscript Type Minireviews
Article Title Pharmacogenetics of type 2 diabetes mellitus: An example of success in clinical and translational medicine
Manuscript Source Invited Manuscript
All Author List Antonio Brunetti, Francesco S Brunetti and Eusebio Chiefari
Funding Agency and Grant Number
Corresponding Author Antonio Brunetti, Professor, Department of Health Sciences, University “Magna Græcia” of Catanzaro, V.le Europa (Loc. Germaneto), 88100 Catanzaro, Italy. brunetti@unicz.it
Key Words Type 2 diabetes; Anti-diabetic drugs; Personalized therapy; Genetic variants; Genome-wide association study
Core Tip Type 2 diabetes mellitus (T2DM) is a heterogeneous complex disorder, in which predisposing genetic variants (polymorphisms) and precipitating environmental factors interact synergistically in the development of the disease. Besides being useful in identifying individuals at risk for T2DM, knowledge of the polymorphisms associated with T2DM is also useful in pharmacogenetics for correlating individual variants with individual responses to anti-diabetic drugs. To date, a wide variety of genes that influence pharmacogenetics of anti-diabetic drugs have been identified. However, with few exceptions, drug therapy has not taken into account the individual genetic diversity of treated patients, representing, this, a substantial limitation of pharmacogenetics. This review focuses on clinically important polymorphisms affecting a patient’s response to diabetic medications.
Publish Date 2014-12-13 17:57
Citation Brunetti A, Brunetti FS, Chiefari E. Pharmacogenetics of type 2 diabetes mellitus: An example of success in clinical and translational medicine. World J Transl Med 2014; 3(3): 141-149
URL http://www.wjgnet.com/2220-6132/full/v3/i3/141.htm
DOI http://dx.doi.org/10.5528/wjtm.v3.i3.141
Full Article (PDF) WJTM-3-141.pdf
Full Article (Word) WJTM-3-141.doc
Manuscript File 12821-Review.docx
Answering Reviewers 12821-Answering reviewers.pdf
Copyright License Agreement 12821-Copyright assignment.pdf
Peer-review Report 12821-Peer review(s).pdf
Scientific Misconduct Check 12821-CrossCheck.jpg
Scientific Editor Work List 12821-Scientific editor work list.pdf