Publication Name	World Journal of Neurology
Manuscript ID	14348
Country	United Kingdom

Received	2014-09-29 08:17
Peer-Review Started	2014-09-29 11:12
To Make the First Decision	2014-10-14 17:26
Return for Revision	2014-10-20 08:08
Revised	2014-11-11 16:32
Second Decision	2014-11-26 11:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-01 13:47
Articles in Press	2014-12-01 13:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-20 14:02
Publish the Manuscript Online	2014-12-25 18:06

ISSN	2218-6212 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Neurosciences
Manuscript Type	Review
Article Title	Cerebral ageing-the role of insulin and insulin-like growth factor signalling: A review
Manuscript Source	Invited Manuscript
All Author List	Georgia Romain and Jolanta Opacka-Juffry
Funding Agency and Grant Number
Corresponding Author	Jolanta Opacka-Juffry, Professor, Department of Life Sciences, University of Roehampton, SW15 4JD London, United Kingdom. j.opacka-juffry@roehampton.ac.uk
Key Words	Brain; Insulin; Insulin receptor; Insulin-like growth factor; Longevity; Alzheimer’s; Diabetes mellitus; Inflammation
Core Tip	Age itself is a major risk factor for the develop-ment of age-related cognitive decline, Alzheimer’s and cerebrovascular diseases. Increased life expectancy necessitates the need to understand the processes that underlie successful vs pathological brain ageing in order to develop early interventions which may assist in delaying if not reversing the detrimental effects of brain ageing. This review focuses on the signalling system of insulin and insulin-like growth factor-1 (IIS) and its roles in cerebral ageing; it highlights some conflicting literature opinions and incomplete understandings of the roles and mechanisms of the IIS system.
Publish Date	2014-12-25 18:06
Citation	Romain G, Opacka-Juffry J. Cerebral ageing-the role of insulin and insulin-like growth factor signalling: A review. World J Neurol 2014; 4(3): 12-22
URL	http://www.wjgnet.com/2218-6212/full/v4/i3/12.htm
DOI	http://dx.doi.org/10.5316/wjn.v4.i3.12

Full Article (PDF)	WJN-4-12.pdf
Full Article (Word)	WJN-4-12.doc
Manuscript File	14348-Review.docx
Answering Reviewers	14348-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14348-Conflict-of-interest.pdf
Copyright License Agreement	14348-Copyright assignment.pdf
Peer-review Report	14348-Peer review(s).pdf
Scientific Misconduct Check	14348-CorssCheck.jpg
Scientific Editor Work List	14348-Scientific editor work list.pdf