Publication Name	World Journal of Stem Cells
Manuscript ID	14364
Country	Spain

Received	2014-09-30 09:03
Peer-Review Started	2014-10-01 21:42
To Make the First Decision	2014-10-28 14:35
Return for Revision	2014-10-30 17:52
Revised	2014-11-13 23:24
Second Decision	2014-12-10 20:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-17 16:28
Articles in Press	2014-12-17 16:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-02-12 16:03
Publish the Manuscript Online	2015-03-20 10:47

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Review
Article Title	Mesenchymal stem cells as a therapeutic tool to treat sepsis
Manuscript Source	Invited Manuscript
All Author List	Eleuterio Lombardo, Tom van der Poll, Olga DelaRosa and Wilfried Dalemans
Funding Agency and Grant Number	Funding Agency Grant Number Ministerio de Economía y Competitividad (MINECO) Comunidad Autónoma de Madrid (CAM) through the Program Madrid Network
Corresponding Author	Eleuterio Lombardo, PhD, TiGenix SAU, Parque Tecnológico de Madrid, C/Marconi 1, 28760 Tres Cantos, Madrid, Spain. eleuterio.lombardo@tigenix.com
Key Words	Adult mesenchymal stem cells; Therapy; Sepsis
Core Tip	Sepsis remains as the most frequent cause of death in hospitalized patients and, therefore, new therapeutic alternatives are needed. Adult mesenchymal stem cells reduce mortality in experimental models of sepsis by modulating the deregulated inflammatory response against bacteria through the regulation of multiple inflammatory networks, the reprogramming of macrophages and neutrophils towards a more anti-inflammatory phenotype and the release of anti-microbial peptides. In this report we aim to provide a comprehensive snapshot of the potential clinical use of cell therapy with mesenchymal stem cells for sepsis.
Publish Date	2015-03-20 10:47
Citation	Lombardo E, van der Poll T, DelaRosa O, Dalemans W. Mesenchymal stem cells as a therapeutic tool to treat sepsis. World J Stem Cells 2015; 7(2): 368-379
URL	http://www.wjgnet.com/1948-0210/full/v7/i2/368.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i2.368

Full Article (PDF)	WJSC-7-368.pdf
Full Article (Word)	WJSC-7-368.doc
Manuscript File	14364-Review.doc
Answering Reviewers	14364-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14364-Conflict-of-interest statement.pdf
Copyright License Agreement	14364-Copyright assignment.pdf
Peer-review Report	14364-Peer review(s).pdf
Scientific Misconduct Check	14364-CrossCheck.jpg
Scientific Editor Work List	14364-Scientific editor work list.pdf