Publication Name	World Journal of Orthopedics
Manuscript ID	17118
Country	Egypt

Received	2015-02-13 10:34
Peer-Review Started	2015-02-13 13:21
To Make the First Decision	2015-05-13 19:15
Return for Revision	2015-05-19 16:34
Revised	2015-05-31 07:39
Second Decision	2015-07-06 08:35
Accepted by Journal Editor-in-Chief	2015-07-08 15:50
Accepted by Company Editor-in-Chief	2015-07-17 14:28
Articles in Press	2015-07-17 14:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-06 13:41
Publish the Manuscript Online	2015-09-18 16:17

ISSN	2218-5836 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Recent biological trends in management of fracture non-union
Manuscript Source	Invited Manuscript
All Author List	Khaled M Emara, Ramy Ahmed Diab and Ahmed Khaled Emara
Funding Agency and Grant Number
Corresponding Author	Dr. Khaled M Emara, Professor, Department of Orthopaedic Surgery, Ain Shams University, 13 B Kornish elNile, Agha Khan, Cairo 11511, Egypt. kmemara@hotmail.com
Key Words	Biological; Fracture repair; Nonunion; Cell therapy; Bone substitutes
Core Tip	Successful fracture healing requires mechanical stability and a viable biologic microenvironment. Fractures with compromised biology will benefit from treatment options that can augment the biologic potential at the site of bone repair. An ideal bone graft should be osteoinductive, osteoconductive, osteogenic, angiogenic and should provide mechanical support and promote physiologic healing without any significant adverse effects. Regenerative strategies like the use of bone morphogenic proteins, platelet rich plasma, stem cells and anabolic agents are promising in the treatment of fractures either acute or fracture non-union.
Publish Date	2015-09-18 16:17
Citation	Emara KM, Diab RA, Emara AK. Recent biological trends in management of fracture non-union. World J Orthop 2015; 6(8): 623-628
URL	http://www.wjgnet.com/2218-5836/full/v6/i8/623.htm
DOI	http://dx.doi.org/10.5312/wjo.v6.i8.623

Full Article (PDF)	WJO-6-623.pdf
Full Article (Word)	WJO-6-623.doc
Manuscript File	17118-Review.docx
Answering Reviewers	17118-Answering reviewers.pdf
Audio Core Tip	17118-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17118-Conflict-of-interest statement.pdf
Copyright License Agreement	17118-Copyright assignment.pdf
Peer-review Report	17118-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17118-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17118-Scientific misconduct check.pdf
Scientific Editor Work List	17118-Scientific editor work list.pdf