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2/1/2016 4:46:00 PM | Browse: 461 | Download: 1239
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Received |
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2015-08-07 14:07 |
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Peer-Review Started |
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2015-08-11 15:06 |
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To Make the First Decision |
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2015-09-16 13:59 |
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Return for Revision |
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2015-09-22 10:41 |
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Revised |
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2015-10-10 00:51 |
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Second Decision |
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2015-11-23 09:20 |
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Accepted by Journal Editor-in-Chief |
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2015-11-24 10:33 |
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Accepted by Company Editor-in-Chief |
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2015-12-15 09:04 |
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Articles in Press |
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2015-12-15 09:04 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-01-25 16:10 |
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Publish the Manuscript Online |
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2016-02-01 13:23 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Observational Study |
| Article Title |
Neuropathology of JC virus infection in progressive multifocal leukoencephalopathy in remission
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Karen S SantaCruz, Gulmohor Roy, James Spigel and Elaine L Bearer |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The Harvey Family Endowment (ELB) and National Institutes of Health |
RO1 MH096093 |
| The Harvey Family Endowment (ELB) and National Institutes of Health |
RO1 NS062184 |
| The Harvey Family Endowment (ELB) and National Institutes of Health |
RO1 NS046810 |
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| Corresponding Author |
Elaine L Bearer, Professor, Department of Pathology, University of New Mexico, University of New Mexico Health Sciences Center, UNM Hospital (MSC08 4640), Albuquerque, NM 87131, United States. ebearer@salud.unm.edu |
| Key Words |
Progressive multifocal leukoencephalopathy; Progressive multifocal leukoencephalopathy; JC virus; Remission; Demyelinating |
| Core Tip |
Progressive multifocal leukoencephalopathy after organ transplant is rapidly fatal in most cases, with an average time to death of 6.4 mo. We report a case with no clinical progression over 14 years despite on-going immunosuppressive therapy. At initial diagnosis the biopsy demonstrated classic histopathological features of JC virus. At autopsy, microscopic analysis of the cerebellar lesion revealed a residual loss of myelin and evidence of axonal damage without evidence of viral activity. These results suggest that JC virus can be kept in check even in a setting of immunosuppression, and argue for more investigation into the microbiome of the brain. |
| Publish Date |
2016-02-01 13:23 |
| Citation |
SantaCruz KS, Roy G, Spigel J, Bearer EL. Neuropathology of JC virus infection in progressive multifocal leukoencephalopathy in remission. World J Virol 2016; 5(1): 31-37 |
| URL |
http://www.wjgnet.com/2220-3249/full/v5/i1/31.htm |
| DOI |
http://dx.doi.org/10.5501/wjv.v5.i1.31 |
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