Publication Name	World Journal of Virology
Manuscript ID	22098
Country	Colombia

Received	2015-08-12 08:42
Peer-Review Started	2015-08-13 14:28
First Decision by Editorial Office Director
Return for Revision	2015-10-06 11:39
Revised	2015-10-23 01:52
Publication Fee Transferred
Second Decision by Editor	2016-01-20 16:30
Second Decision by Editor-in-Chief	2016-01-22 14:36
Final Decision by Editorial Office Director	2016-01-29 17:14
Articles in Press	2016-01-29 17:15
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-13 11:30
Publish the Manuscript Online	2016-05-06 13:48

ISSN	2220-3249 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Review
Article Title	Inflammatory and oxidative stress in rotavirus infection
Manuscript Source	Invited Manuscript
All Author List	Carlos A Guerrero and Orlando Acosta
Funding Agency and Grant Number
Corresponding Author	Carlos A Guerrero, MD, MSc, PhD, Professor of Medicine, Department of Physiological Sciences, Faculty of Medicine, Universidad Nacional de Colombia, Carrera 45 # 26-85, Bogotá 111311, Colombia. caguerrerof@unal.edu.co
Key Words	Rotaviruses; Oxidative stress; Inflammatory signaling; Antioxidant treatment; Anti-inflammatory treatment
Core Tip	Rotavirus entry into the host cell requires cell surface molecules providing binding, chaperoning and oxido-reducing functions. Sialic acid/integrin a2b1, heat shock cognate protein 70 and protein disulfide isomerase (PDI) seem to perform these functions. Recently, the cell surface oxido-reduction activity based at least on PDI has been highlighted as a potential determinant of the conformational changes that are required by viral structural proteins in order to facilitate virus entry. The rotavirus-induced oxidative stress and inflammatory signaling is an attractive target for therapeutic intervention as antioxidant and anti-inflammatory treatment has proved to efficiently inhibit rotavirus infection.
Publish Date	2016-05-06 13:48
Citation	Guerrero CA, Acosta O. Inflammatory and oxidative stress in rotavirus infection. World J Virol 2016; 5(2): 38-62
URL	http://www.wjgnet.com/2220-3249/full/v5/i2/38.htm
DOI	http://dx.doi.org/10.5501/wjv.v5.i2.38

Full Article (PDF)	WJV-5-38.pdf
Full Article (Word)	WJV-5-38.doc
Manuscript File	22098-Review.docx
Answering Reviewers	22098-Answering reviewers.pdf
Audio Core Tip	22098-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22098-Conflict-of-interest statement.pdf
Copyright License Agreement	22098-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20150812001950.docx
Peer-review Report	22098-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22098-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22098-Scientific misconduct check.pdf
Scientific Editor Work List	22098-Scientific editor work list.pdf