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5/10/2016 2:10:00 PM | Browse: 419 | Download: 1114
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Received |
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2016-01-10 16:34 |
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Peer-Review Started |
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2016-01-10 18:56 |
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To Make the First Decision |
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2016-01-28 14:46 |
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Return for Revision |
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2016-01-28 15:17 |
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Revised |
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2016-01-30 13:29 |
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Second Decision |
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2016-02-22 13:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2016-03-02 09:28 |
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Articles in Press |
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2016-03-02 09:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-03-22 07:09 |
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Typeset the Manuscript |
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2016-04-21 17:14 |
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Publish the Manuscript Online |
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2016-05-04 10:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Peer-review started: February 25, 2016 |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
miR-30b inhibits autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Peng Li, Jin-Dan He, Zhen Wang, Yao Yu, Shu-Yu Fu, Hai-Ming Zhang, Jian-Jun Zhang and Zhong-Yang Shen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National High-tech R&D Program of China (863 Program) |
2012AA021001 |
| National Natural Science Foundation of China |
81270554 |
| Special Fund for Health Research in the Public Interest of China |
201302009 |
| National Key Specialty Construction of Clinical Projects |
201354409 |
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| Corresponding Author |
Jian-Jun Zhang, MD, PhD, First Central Clinical College of Tianjin Medical University, Oriental Organ Transplant Center of Tianjin First Central Hospital, Key Laboratory of Organ Transplantation of Tianjin, No. 24 Fukang Road, Nankai District, Tianjin 300192, China. zhangjianjun9999@yeah.net |
| Key Words |
miR-30b; Autophagy; Atg12-Atg5 conjugate; Hepatic ischemia-reperfusion injury |
| Core Tip |
miR-30b levels were significantly downregulated after hepatic ischemia-reperfusion injury (IRI) in mice. The number of autophagosomes was increased in response to IRI both in vivo and in vitro. Decreased levels of miR-30b could promote hepatic IRI, as revealed by reductions in cells viability in vitro. Overexpression of miR-30b diminished autophagy-related gene (Atg)12 and Atg12-Atg5 conjugate levels which promoted autophagy in response to hepatic IRI. Therefore, miR-30b inhibits autophagy to alleviate hepatic IRI via decreasing the Atg12-Atg5 conjugate. |
| Publish Date |
2016-05-04 10:08 |
| Citation |
Li SP, He JD, Wang Z, Yu Y, Fu SY, Zhang HM, Zhang JJ, Shen ZY. miR-30b inhibits autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate. World J Gastroenterol 2016; 22(18): 4501-4514 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i18/4501.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i18.4501 |
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