Publication Name	World Journal of Virology
Manuscript ID	26698
Country	Greece

Received	2016-04-22 14:39
Peer-Review Started	2016-04-23 08:02
First Decision by Editorial Office Director
Return for Revision	2016-06-06 15:46
Revised	2016-06-24 22:48
Publication Fee Transferred
Second Decision by Editor	2016-08-11 10:50
Second Decision by Editor-in-Chief	2016-08-12 09:15
Final Decision by Editorial Office Director	2016-08-18 11:24
Articles in Press	2016-08-18 11:24
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-10-31 15:17
Publish the Manuscript Online	2016-11-08 20:12

ISSN	2220-3249 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Virology
Manuscript Type	Basic Study
Article Title	Antiretroviral naive and treated patients: Discrepancies of B cell subsets during the natural course of human immunodeficiency virus type 1 infection
Manuscript Source	Invited Manuscript
All Author List	Olga Tsachouridou, Lemonia Skoura, Pantelis Zebekakis, Apostolia Margariti, Adamantini Georgiou, Dimitrios Bougiouklis, Dimitrios Pilalas, Antonios Galanos, Michael Daniilidis and Symeon Metallidis
Funding Agency and Grant Number
Corresponding Author	Olga Tsachouridou, MD, PhD, Research Associate of Infectious Diseases Unit, 1st Internal Medicine Department, Infectious Diseases Division, Medical School, Aristotle University of Thessaloniki, 1 Stilponos Kyriakidi Street, 54636 Thessaloniki, Greece. olgat_med@hotmail.com
Key Words	B cell subpopulations; Time-trend; Memory cells; Human immunodeficiency virus infection; Highly active antiretroviral therapy
Core Tip	During the progress of human immunodefi-ciency virus (HIV) infection and viral replication functional irritations of memory B-cell (BMC) compart-ment occur. Depletion of BMCs is one hallmark of deregulation in HIV-1 infection. Diminished levels of IgM+ BMCs are also noted. Additionally, resting BMCs are severely impaired and defective B-cell subsets, like exhausted and activated BMCs circulate in peripheral blood. Significant fluctuations of these B cells’ frequencies are recorded over time and antiretroviral therapy may play a role on this observation. Assessing these populations could potentially lead to improvement in assessing vaccine responses and tracing vulnerable patients to certain infections.
Publish Date	2016-11-08 20:12
Citation	Tsachouridou O, Skoura L, Zebekakis P, Margariti A, Georgiou A, Bougiouklis D, Pilalas D, Galanos A, Daniilidis M, Metallidis S. Antiretroviral naive and treated patients: Discrepancies of B cell subsets during the natural course of human immunodeficiency virus type 1 infection. World J Virol 2016; 5(4): 155-160
URL	http://www.wjgnet.com/2220-3249/full/v5/i4/155.htm
DOI	http://dx.doi.org/10.5501/wjv.v5.i4.155

Full Article (PDF)	WJV-5-155.pdf
Full Article (Word)	WJV-5-155.doc
Manuscript File	26698-Review.docx
Answering Reviewers	26698-Answering reviewers.pdf
Audio Core Tip	26698-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26698-Conflict-of-interest statement.pdf
Copyright License Agreement	26698-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20160422143729.docx
Institutional Animal Care and Use Committee Approval Form or Document	26698-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	26698-Institutional review board statement.pdf
Peer-review Report	26698-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	26698-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	26698-Scientific misconduct check.pdf
Scientific Editor Work List	26698-Scientific editor work list.pdf