Publication Name	World Journal of Gastroenterology
Manuscript ID	26959
Country	Japan

Received	2016-05-01 14:29
Peer-Review Started	2016-05-02 15:04
First Decision by Editorial Office Director
Return for Revision	2016-06-20 17:31
Revised	2016-07-19 00:57
Publication Fee Transferred
Second Decision by Editor	2016-07-30 14:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-08-05 17:53
Articles in Press	2016-08-05 17:53
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-09-28 20:37
Publish the Manuscript Online	2016-10-12 14:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Virology
Manuscript Type	Minireviews
Article Title	Elucidation of the early infection machinery of hepatitis B virus by using bio-nanocapsule
Manuscript Source	Invited Manuscript
All Author List	Qiushi Liu, Masaharu Somiya and Shun’ichi Kuroda
Funding Agency and Grant Number
Corresponding Author	Shun’ichi Kuroda, PhD, Professor, Department of Biomolecular Science and Reaction, The Institute of Scientific and Industrial Research, Osaka University, Ibaraki 567-0047, Japan. skuroda@sanken.osaka-u.ac.jp
Key Words	Bio-nanocapsule; Endosomal escape; Hepatitis B virus; Heparan sulfate proteoglycan; Sodium taurocholate cotransporting polypeptide
Core Tip	Owing to the poor availability and the difficulty of manipulations of hepatitis B virus (HBV), it has been difficult to analyze its early infection events in human hepatocytes. Using a bio-nanocapsule, a unique model of HBV, we could study these events by biochemical and cytochemical methods, and finally identify a low pH-dependent fusogenic domain in HBV pre-S1 region, which might play a pivotal role in the endosomal escape of HBV. We hereby postulate a model in which each domain in HBV envelope L protein participates in cell attachment, endocytosis, membrane fusion, and consequent endosomal escape (i.e., uncoating process of HBV).
Publish Date	2016-10-12 14:18
Citation	Liu Q, Somiya M, Kuroda S. Elucidation of the early infection machinery of hepatitis B virus by using bio-nanocapsule. World J Gastroenterol 2016; 22(38): 8489-8496
URL	http://www.wjgnet.com/1007-9327/full/v22/i38/8489.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i38.8489

Full Article (PDF)	WJG-22-8489.pdf
Full Article (Word)	WJG-22-8489.doc
Manuscript File	26959-Review.docx
Answering Reviewers	26959-Answering reviewers.pdf
Audio Core Tip	26959-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	26959-Conflict-of-interest statement.pdf
Copyright License Agreement	26959-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	26959-Language certificate.pdf
Peer-review Report	26959-Peer-review(s).pdf
Scientific Misconduct Check	26959-Scientific misconduct check.pdf
Scientific Editor Work List	26959-Scientific editor work list.pdf