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9/28/2017 10:11:29 AM | Browse: 1009 | Download: 1302
Publication Name World Journal of Gastroenterology
Manuscript ID 32657
Country/Territory Japan
Received
2017-01-18 20:28
Peer-Review Started
2017-01-20 11:11
To Make the First Decision
2017-03-16 11:33
Return for Revision
2017-03-17 15:10
Revised
2017-08-24 01:46
Second Decision
2017-08-30 02:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-09-05 18:46
Articles in Press
2017-09-05 18:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-25 12:32
Publish the Manuscript Online
2017-09-28 10:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury
Manuscript Source Invited Manuscript
All Author List Mitsuhiko Abe, Takafumi Yoshida, Jun Akiba, Yu Ikezono, Fumitaka Wada, Atsutaka Masuda, Takahiko Sakaue, Toshimitsu Tanaka, Hideki Iwamoto, Toru Nakamura, Michio Sata, Hironori Koga, Akihiko Yoshimura and Takuji Torimura
Funding Agency and Grant Number
Funding Agency Grant Number
JSPS Grant-in-Aid for Scientific Research (C) 16K09385
Corresponding Author Takafumi Yoshida, MD, PhD, Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume Clinical Pharmacology Clinic.67 Asahi-Machi, Kurume 830-0011, Japan. tayoshi@med.kurume-u.ac.jp
Key Words Hepatocellular carcinoma; Ductular reaction; Signal transducer and activator of transcription 3; Yes-associated protein; Sex determining region Y-box9; Transdifferentiation
Core Tip Cell transdifferentiation has been identified as one of the crucial sources of organ regeneration. In liver regeneration, both mature hepatocytes and cholangiocytes have been shown to transdiffrentiate to each other to maintain hepatic homeostasis. Although STAT3 has been also shown to be implicated in cellular differentiation, the differentiative role of STAT3 in liver regeneration remains unknown. In this study, we found that hepatic-STAT3 deficiency promoted biliary ductular proliferation with upregulation of YAP/SOX9, crucial regulators of transdifferentiation, in liver injury of mice. This work suggests that STAT3 determines liver cell fate regulating YAP/SOX9 in liver regeneration.
Publish Date 2017-09-28 10:01
Citation Abe M, Yoshida T, Akiba J, Ikezono Y, Wada F, Masuda A, Sakaue T, Tanaka T, Iwamoto H, Nakamura T, Sata M, Koga H, Yoshimura A, Torimura T. STAT3 deficiency prevents hepatocarcinogenesis and promotes biliary proliferation in thioacetamide-induced liver injury. World J Gastroenterol 2017; 23(37): 6833-6844
URL http://www.wjgnet.com/1007-9327/full/v23/i37/6833.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i37.6833
Full Article (PDF) WJG-23-6833.pdf
Full Article (Word) WJG-23-6833.doc
Manuscript File 32657-Review.docx
Answering Reviewers 32657-Answering reviewers.pdf
Audio Core Tip 32657-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 32657-Conflict-of-interest statement.pdf
Copyright License Agreement 32657-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32657-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 32657-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 32657-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 32657-Language certificate.pdf
Peer-review Report 32657-Peer-review(s).pdf
Scientific Misconduct Check 32657-Scientific misconduct check.pdf
Scientific Editor Work List 32657-Scientific editor work list.pdf