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8/28/2017 9:09:07 AM | Browse: 185 | Download: 370
Publication Name World Journal of Gastroenterology
Manuscript ID 32886
Country of Manuscript Source Sweden
2017-01-30 12:57
Peer-Review Started
2017-02-01 00:21
To Make the First Decision
2017-04-05 17:18
Return for Revision
2017-04-05 18:57
2017-04-26 19:45
Second Decision
2017-06-16 12:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2017-06-19 08:40
Articles in Press
2017-06-19 08:40
Publication Fee Transferred
2017-07-07 02:21
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-08-15 12:00
Publish the Manuscript Online
2017-08-28 06:54
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Clinical Trials Study
Article Title Characterizing gastrointestinal stromal tumors and evaluating neoadjuvant imatinib by sequencing of endoscopic ultrasound-biopsies
Manuscript Source Unsolicited Manuscript
All Author List Per Hedenström, Bengt Nilsson, Akif Demir, Carola Andersson, Fredrik Enlund, Ola Nilsson and Riadh Sadik
Funding Agency and Grant Number
Funding Agency Grant Number
The Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland VGFOUREG-564381
The Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland VGFOUREG-665681
The Health and Medical Care Committee of the Regional Executive Board, Region Västra Götaland VGFOUREG-373551
Sahlgrenska University Hospital LUA-ALF 73830
The Swedish Society of Medicine SLS-404261
The Swedish Society of Medicine SLS-325061
Correspondence To Dr. Riadh Sadik, Associate Professor, Division of Medical Gastroenterology, Department of Internal Medicine, Sahlgrenska University Hospital, Blå Stråket 3, S-413 45 Gothenburg, Sweden. riadh.sadik@vgregion.se
Keywords Endosonography; Fine-needle biopsy; Gastrointestinal stromal tumor; KIT; Platelet-derived growth factor alpha; Tumor proliferation rate; Ki-67 index; Neoadjuvant treatment; Imatinib
Core Tip Personalization of the management and treatment of gastrointestinal stromal tumors (GIST) requires an extensive characterization of individual tumors. Information on the tumor proliferation rate and the KIT- and platelet-derived growth factor alpha (PDGFRA)-mutation profile is essential. While endoscopic ultrasound (EUS)-FNA is reported to be suboptimal for the diagnosis of GIST, EUS-guided biopsy sampling (EUS-FNB) has not been evaluated for the characterization of GISTs. This prospective, long-term study showed that EUS-FNB was safe and highly accurate for the pretreatment diagnosis of GISTs, for the sequencing of KIT and PDGFRA, and for the assessment of the tumor proliferation rate (Ki-67-index). By obtaining this information, we managed to guide and evaluate neoadjuvant imatinib therapy in patients with GIST.
Publish Date 2017-08-28 06:54
Citation Hedenström P, Nilsson B, Demir A, Andersson C, Enlund F, Nilsson O, Sadik R. Characterizing gastrointestinal stromal tumors and evaluating neoadjuvant imatinib by sequencing of endoscopic ultrasound-biopsies. World J Gastroenterol 2017; 23(32): 5925-5935
Url http://www.wjgnet.com/1007-9327/full/v23/i32/5925.htm
DOI http://dx.doi.org/10.3748/wjg.v23.i32.5925
Full Article (PDF) WJG-23-5925.pdf
Full Article (Word) WJG-23-5925.doc
Revised Manuscript 32886-Review.docx
Peer-review Report 32886-Peer-review(s).pdf
Answering Reviewers 32886-Answering reviewers.pdf
Scientific Misconduct Check 32886-Scientific misconduct check.pdf
Scientific Editor Work List 32886-Scientific editor work list.pdf
Audio Core Tip 32886-Audio core tip.mp3
Biostatistics Review Certificate 32886-Biostatistics statement.pdf
Clinical Trial Registration Statement 32886-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 32886-Conflict-of-interest statement.pdf
Copyright License Agreement 32886-Copyright assignment.pdf
Data Sharing Statement 32886-Data sharing statement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 32886-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 32886-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 32886-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 32886-Language certificate.pdf
Scientific Research Process 32886-Scientific research process.pdf
Supplementary Material 32886-Supplementary material.pdf