Publication Name	World Journal of Gastroenterology
Manuscript ID	32908
Country	Germany

Received	2017-01-30 14:20
Peer-Review Started	2017-02-01 11:44
To Make the First Decision	2017-03-16 13:20
Return for Revision	2017-03-20 16:50
Revised	2017-04-04 05:50
Second Decision	2017-05-18 03:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2017-05-19 07:58
Articles in Press	2017-05-19 07:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2017-06-26 09:18
Publish the Manuscript Online	2017-07-12 06:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Can a fibrotic liver afford epithelial-mesenchymal transition?
Manuscript Source	Invited Manuscript
All Author List	Stefen Munker, Yong-Le Wu, Hui-Guo Ding, Roman Liebe and Hong-Lei Weng
Funding Agency and Grant Number	Funding Agency Grant Number Chinese-German Cooperation Group projec GZ 1263 The National Science Fund 81672725 the Capital Science and Technology Development Fund 2014-1-2181 Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding ZYLX201610
Corresponding Author	Hong-Lei Weng, PhD, Principle Investigator, Department of Medicine II, Section Molecular Hepatology, Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer Ufer 1-3, 68167 Mannheim, Germany. honglei.weng@medma.uni-heidelberg.de
Key Words	Epithelial-mesenchymal transition; Liver fibrosis; Liver cirrhosis; Transforming growth factor-β
Core Tip	This review provides a personal notion about whether a complete epithelial-mesenchymal transition (EMT) occurs in human fibrotic livers. We consider three aspects that might determine the occurrence of EMT: (1) capacity of parenchymal cells; (2) potential benefit for the liver and the whole body; and (3) micro­environment within a fibrotic liver. Clinical evidence suggests that in humans, EMT-like alterations occur mainly in advanced chronic liver disease, i.e., cirrhosis. In such a severe disease state, the most urgent mission for a liver is to maintain a maximum number of functional hepatocytes, while hepatic stellate cells and portal fibroblasts provide an ample supply of myofibroblasts. It appears that there is no need for additional sources of myofibroblasts in a cirrhotic liver. EMT-like alterations in parenchymal cells are most likely a side effect of high levels of EMT-promoting factors such as TGF-β.
Publish Date	2017-07-12 06:45
Citation	Munker S, Wu YL, Ding HG, Liebe R, Weng HL. Can a fibrotic liver afford epithelial-mesenchymal transition? World J Gastroenterol 2017; 23(26): 4661-4668
URL	http://www.wjgnet.com/1007-9327/full/v23/i26/4661.htm
DOI	http://dx.doi.org/10.3748/wjg.v23.i26.4661

Full Article (PDF)	WJG-23-4661.pdf
Full Article (Word)	WJG-23-4661.doc
Manuscript File	32908-Review.docx
Answering Reviewers	32908-Answering reviewers.pdf
Audio Core Tip	32908-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	32908-Conflict-of-interest statement.pdf
Copyright License Agreement	32908-Copyright assignment.pdf
Peer-review Report	32908-Peer-review(s).pdf
Scientific Misconduct Check	32908-Scientific misconduct check.pdf
Scientific Editor Work List	32908-Scientific editor work list.pdf