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9/7/2017 6:18:45 AM | Browse: 41 | Download: 79
Publication Name World Journal of Hepatology
Manuscript ID 33960
Country of Manuscript Source Japan
Received
2017-03-17 09:06
Peer-Review Started
2017-03-17 14:55
To Make the First Decision
2017-05-03 14:52
Return for Revision
2017-05-05 14:27
Revised
2017-05-17 11:44
Second Decision
2017-06-21 00:38
Accepted by Journal Editor-in-Chief
2017-06-21 08:04
Accepted by Company Editor-in-Chief
2017-07-17 06:17
Articles in Press
2017-07-17 06:17
Publication Fee Transferred
2017-07-27 13:17
Edit the Manuscript by Language Editor
Typeset the Manuscript
2017-09-05 02:46
Publish the Manuscript Online
2017-09-07 02:39
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions
Manuscript Source Unsolicited Manuscript
All Author List Hideki Fujii, Atsushi Umemura, Taichiro Nishikawa, Kanji Yamaguchi, Michihisa Moriguchi, Hideki Nakamura, Kohichiroh Yasui, Masahito Minami, Saiyu Tanaka, Hiroki Ishikawa, Hiroyuki Kimura, Shiro Takami, Yasuyuki Nagao, Toshihide Shima and Yoshito Itoh
Funding Agency and Grant Number
Correspondence To Hideki Fujii, MD, PhD, Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiichou, Kamigyouku, Kyoto 6028566, Japan. fuhideki@koto.kpu-m.ac.jp
Keywords Hepatitis C; Asunaprevir; Combination therapy; Resistance-associated substitutions; Daclatasvir
Core Tip Hepatitis C - infected patients treated with daclatasvir and asunaprevir were evaluated for sustained virological response (SVR) according to pretreatment factors. The overall rate of SVR12 was 88.3%. The SVR12 rate in the ≥ 6.0 log IU/mL group was significantly lower than in the < 6.0 log IU/mL group. The SVR12 rate in Y93 substitution-positive patients was significantly lower than that in non-Y93 substitution patients. The L31 substitution-positive group had a lower SVR 12 rate than the L31 substitution-negative group. Seventeen patients who did not achieve SVR 12 had additional RASs in NS3:D168, NS5:L31, and Y93 post-treatment. Baseline RASs should be thoroughly assessed to avoid additional RASs after treatment failure.
Publish Date 2017-09-07 02:39
Citation Fujii H, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Nakamura H, Yasui K, Minami M, Tanaka S, Ishikawa H, Kimura H, Takami S, Nagao Y, Shima T, Itoh Y. Real-world efficacy of daclatasvir and asunaprevir with respect to resistance-associated substitutions. World J Hepatol 2017; 9(25): 1064-1072
Url http://www.wjgnet.com/1948-5182/full/v9/i25/1064.htm
DOI http://dx.doi.org/10.4254/wjh.v9.i25.1064
Full Article (PDF) WJH-9-1064.pdf
Full Article (Word) WJH-9-1064.doc
Revised Manuscript 33960-Review.docx
Peer-review Report 33960-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 33960-Journal editor-in-chief review report.pdf
Answering Reviewers 33960-Answering reviewers.pdf
Scientific Misconduct Check 33960-Scientific misconduct check.pdf
Scientific Editor Work List 33960-Scientific editor work list.pdf
Audio 33960-Audio core tip.mp3
Biostatistics Statement 33960-Biostatistics statement.pdf
Conflict-of-Interest Statement 33960-Conflict-of-interest statement.pdf
Copyright Assignment 33960-Copyright assignment.pdf
Data Sharing Statement 33960-Data sharing statement.pdf
Informed Consent Statement 33960-Informed consent statement.pdf
Institutional Review Board Statement 33960-Institutional review board statement.pdf
Non-Native Speakers of English 33960-Language certificate.pdf
Scientific Research Process 33960-Scientific research process.pdf