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12/29/2017 9:06:54 AM | Browse: 949 | Download: 1280
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Received |
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2017-10-31 01:11 |
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Peer-Review Started |
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2017-10-31 07:58 |
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First Decision by Editorial Office Director |
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2017-11-21 21:59 |
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Return for Revision |
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2017-11-27 06:59 |
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Revised |
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2017-12-04 19:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2017-12-12 08:39 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2017-12-12 19:44 |
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Articles in Press |
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2017-12-12 19:44 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2017-12-19 02:58 |
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Publish the Manuscript Online |
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2017-12-27 11:08 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Editorial |
| Article Title |
Serum levels of angiotensin converting enzyme as a biomarker of liver fibrosis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Aline Silva Miranda and Ana Cristina Simoes e Silva |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CNPq |
460334/2014-0 |
| FAPEMIG |
CDS - PPM-00555-15 |
| 2016 NARSAD Young Investigator Grant Awardee from the Brain and Behavior Research Foundation |
25414 |
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| Corresponding Author |
Ana Cristina Simoes e Silva, MD, PhD, Professor, Research Scientist, Departament of Pediatrics, Pediatric Nephrology Unit, Universidade Federal de Minas Gerais, Faculty of Medicine, UFMG. Alfredo Balena Avenue, Number 190, 2nd floor, Room # 281, Belo Horizonte 30130-100, Minas Geris, Brazil. acssilva@hotmail.com |
| Key Words |
Renin angiotensin system; Angiotensin converting enzyme; Angiotensin II; Angiotensin-(1-7); Chronic hepatitis B; Hepatic cirrhosis; Liver fibrosis |
| Core Tip |
The therapeutic intervention for patients with chronic hepatitis B (CHB) frequently relies on the pathological classification of liver fibrosis severity in biopsy. The establishment of non-invasive and accurate methods to detect reversible stages of liver fibrosis is still a challenge. High serum levels of angiotensin converting enzyme seem to better predict liver intermediate fibrosis than other classical fibrotic markers. Non-invasive methods to detect with very good accuracy intermediate stages of liver fibrosis may permit the introduction and/or evaluation of treatments during reversible stages of the disease. Further studies are urgently necessary to fully clarify the role of RAS components in liver disease. |
| Publish Date |
2017-12-27 11:08 |
| Citation |
Miranda AS, Simões e Silva AC. Serum levels of angiotensin converting enzyme as a biomarker of liver fibrosis. World J Gastroenterol 2017; 23(48): 8439-8442 |
| URL |
http://www.wjgnet.com/1007-9327/full/v23/i48/8439.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v23.i48.8439 |
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