Publication Name	World Journal of Gastroenterology
Manuscript ID	37126
Country	Australia

Received	2017-11-14 17:17
Peer-Review Started	2017-11-15 08:11
To Make the First Decision	2017-11-30 05:56
Return for Revision	2017-12-03 06:57
Revised	2017-12-06 11:15
Second Decision	2017-12-12 08:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2017-12-12 19:33
Articles in Press	2017-12-12 19:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2018-01-05 00:52
Publish the Manuscript Online	2018-01-07 04:21

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Estrogen, estrogen receptors, and hepatocellular carcinoma: are we there yet?
Manuscript Source	Invited Manuscript
All Author List	Olga A Sukocheva
Funding Agency and Grant Number
Corresponding Author	Olga A Sukocheva, MSc, PhD, Academic Research, Health Sciences, Flinders University of South Australia, Flinders Drive, Bedford Park 5042, South Australia, Australia. olga.sukocheva@flinders.edu.au
Key Words	Hepatocellular carcinoma; Hepatitis C virus; Hepatitis; Estrogen receptors; Cirrhosis
Core Tip	Recent discoveries confirmed that the female sex hormone estrogen protects against the development and progression of hepatocellular carcinoma (HCC). However, the mechanism of estrogen’s anti-oncogenic effects and the specific impact of estrogen receptor (ER) signalling in HCC are unclear and controversial. It is essential to determine how to exploit the estrogen signalling pathway within a clinical setting for HCC treatment. The current editorial review critically analyses the Iyer et al (WJG, 2017) study that investigated the expression of ER subtypes in liver samples collected from patients with a healthy liver, hepatitis C virus cirrhosis, and HCC.
Publish Date	2018-01-07 04:21
Citation	Sukocheva OA. Estrogen, estrogen receptors, and hepatocellular carcinoma: are we there yet? World J Gastroenterol 2018; 24(1): 1-4
URL	http://www.wjgnet.com/1007-9327/full/v24/i1/1.htm
DOI	http://dx.doi.org/10.3748/wjg.v24.i1.1

Full Article (PDF)	WJG-24-1.pdf
Full Article (Word)	WJG-24-1.doc
Manuscript File	37126-Review.docx
Answering Reviewers	37126-Answering reviewers.pdf
Audio Core Tip	37126-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	37126-Conflict-of-interest statement.pdf
Copyright License Agreement	37126-Copyright license agreement.pdf
Supplementary Material	37126-Supplementary-Material-revision.docx
Peer-review Report	37126-Peer-review(s).pdf
Scientific Misconduct Check	37126-Scientific misconduct check.pdf
Scientific Editor Work List	37126-Scientific editor work list.pdf