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4/8/2018 1:18:54 AM | Browse: 728 | Download: 646
Publication Name World Journal of Gastroenterology
Manuscript ID 38133
Country/Territory Spain
Received
2018-01-28 03:15
Peer-Review Started
2018-01-28 09:51
To Make the First Decision
2018-02-10 08:24
Return for Revision
2018-02-11 04:34
Revised
2018-02-16 22:11
Second Decision
2018-02-25 10:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-02-25 23:01
Articles in Press
2018-02-25 23:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-04-03 05:51
Publish the Manuscript Online
2018-04-04 13:15
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Dissecting the molecular pathophysiology of drug-induced liver injury
Manuscript Source Unsolicited Manuscript
All Author List Hui Ye, Leonard J Nelson, Manuel Gómez del Moral, Eduardo Martínez-Naves and Francisco Javier Cubero
Funding Agency and Grant Number
Funding Agency Grant Number
MINECO RyC2014-15242
MINECO SAF2016-78711
Corresponding Author Francisco Javier Cubero, BSc, MSc, PhD, Assistant Professor, Department of Immunology, Complutense University School of Medicine, Plaza Ramón y Cajal s/n, Madrid 28040, Spain. fcubero@ucm.es
Key Words Signaling pathways; Acetaminophen; Drug-induced liver injury; Cell death; Reactive oxygen species
Core Tip Drug-induced liver injury (DILI) represents a broad spectrum of clinical manifestations, and is generally divided into two subtypes: intrinsic and idiosyncratic hepatotoxicity. Drugs and their reactive metabolites covalently bind to mitochondria and cause direct hepatic toxicity through accumulation of oxidative stress (ROS and RNS), endoplasmic reticulum stress and mitochondrial dysfunction, ultimately leading to cell death. The innate and adaptive immune responses also play an important role in the occurrence of idiosyncratic immunological reactions towards the drugs. In this review, we discuss the pathophysiological mechanisms underlying DILI, specific signaling pathways and the common forms of hepatocyte death.
Publish Date 2018-04-04 13:15
Citation Ye H, Nelson LJ, Gómez del Moral M, Martínez-Naves E, Cubero FJ. Dissecting the molecular pathophysiology of drug-induced liver injury. World J Gastroenterol 2018; 24(13): 1373-1385
URL http://www.wjgnet.com/1007-9327/full/v24/i13/1373.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i13.1373
Full Article (PDF) WJG-24-1373.pdf
Full Article (Word) WJG-24-1373.doc
Manuscript File 38133-Review.docx
Answering Reviewers 38133-Answering reviewers.pdf
Audio Core Tip 38133-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 38133-Conflict-of-interest statement.pdf
Copyright License Agreement 38133-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 38133-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 38133-Language certificate.pdf
Peer-review Report 38133-Peer-review(s).pdf
Scientific Misconduct Check 38133-Scientific misconduct check.pdf
Scientific Editor Work List 38133-Scientific editor work list.pdf