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11/7/2018 2:45:57 AM | Browse: 173 | Download: 67
Publication Name World Journal of Gastroenterology
Manuscript ID 40713
Country of Manuscript Source Brazil
2018-07-05 00:43
Peer-Review Started
2018-07-05 02:40
To Make the First Decision
2018-08-27 02:26
Return for Revision
2018-08-28 02:36
2018-10-08 01:06
Second Decision
2018-10-15 08:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-15 18:24
Articles in Press
2018-10-15 18:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2018-11-06 03:50
Publish the Manuscript Online
2018-11-07 02:30
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets
Manuscript Source Invited Manuscript
All Author List Hayandra F Nanini, Claudio Bernardazzi, Fernando Castro and Heitor Siffert Pereira de Souza
Funding Agency and Grant Number
Funding Agency Grant Number
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E26/202.781/2017
Conselho Nacional de Desenvolvimento Científico e Tecnológico 302401/2016-4
Correspondence To Heitor Siffert Pereira de Souza, MD, PhD, Associate Research Scientist, Full Professor, Serviço de Gastroenterologia and Laboratório Multidisciplinar de Pesquisa, Departamento de Clínica Médica, Hospital Universitário, Universidade Federal do Rio de Janeiro, Rua Prof. Rodolpho Paulo Rocco 255, Ilha do Fundão, Rio de Janeiro 21941-913, RJ, Brazil. hsouza@hucff.ufrj.br
Keywords Damage-associated molecular patterns; Environmental factors; Epigenetics; Inflammatory bowel disease; Therapeutic targets
Core Tip Damage-associated molecular patterns (DAMPs) are basically endogenous stress molecules expressed or released as a consequence of cell or tissue damage. The release of endogenous DAMPs precipitates a secondary inflammatory response in inflammatory bowel disease (IBD), which may determine a self-sustaining chronic inflammatory process. DAMPs amplify the inflammatory response driven by immune and non-immune cells and promote several pathologic changes, which may be as­sociated with specific disease phenotypes. Excessive or persistent DAMP-mediated signalling can result in epigenetic modifications, which may sustain chronic in­flammation and also characterize IBD phenotypes. Preli­minary studies targeting DAMPs have shown promising beneficial therapeutic effects both in human and ex­perimental IBD.
Publish Date 2018-11-07 02:30
Citation Nanini HF, Bernardazzi C, Castro F, de Souza HSP. Damage-associated molecular patterns in inflammatory bowel disease: From biomarkers to therapeutic targets. World J Gastroenterol 2018; 24(41): 4622-4634
Url http://www.wjgnet.com/1007-9327/full/v24/i41/4622.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i41.4622
Full Article (PDF) WJG-24-4622.pdf
Manuscript File 40713-Review.docx
Answering Reviewers 40713-Answering reviewers.pdf
Audio Core Tip 40713-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 40713-Conflict-of-interest statement.pdf
Copyright License Agreement 40713-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 40713-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 40713-Language certificate.pdf
Peer-review Report 40713-Peer-review(s).pdf
Scientific Misconduct Check 40713-Scientific misconduct check.pdf
Scientific Editor Work List 40713-Scientific editor work list.pdf