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11/16/2018 12:07:25 AM | Browse: 229 | Download: 162
Publication Name World Journal of Gastroenterology
Manuscript ID 41221
Country of Manuscript Source China
2018-08-08 07:10
Peer-Review Started
2018-08-08 07:56
To Make the First Decision
2018-10-08 02:05
Return for Revision
2018-10-08 09:25
2018-10-19 05:20
Second Decision
2018-10-26 07:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2018-10-27 01:00
Articles in Press
2018-10-27 01:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
2018-10-31 02:04
Typeset the Manuscript
2018-11-09 05:53
Publish the Manuscript Online
2018-11-13 08:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Yiguanjian decoction enhances fetal liver stem/progenitor cell-mediated repair of liver cirrhosis through regulation of macrophage activation state
Manuscript Source Unsolicited Manuscript
All Author List Ying Xu, Wei-Wei Fan, Wen Xu, Shi-Li Jiang, Gao-Feng Chen, Cheng Liu, Jia-Mei Chen, Hua Zhang, Ping Liu and Yong-Ping Mu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81173223
National Natural Science Foundation of China 81573948
National Natural Science Foundation of China 81874390
Correspondence To Yong-Ping Mu, PhD, Attending Doctor, Department of gastroenterology and Hepatology, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong district, Shanghai 201203, China. ypmu8888@126.com
Keywords Cirrhosis; Hepatic progenitor cells; Wnt signaling pathway; Macrophage; 2-acetylaminofluorene; Carbon tetrachloride; Yiguanjian decoction
Core Tip Stem cells play an important role in the treat­ment of end-stage liver cirrhosis, but details concerning their differentiation are still controversial. Our previous studies have indicated that Yiguanjian decoction (YGJ) has an anti-hepatic fibrosis effect. However, it remains unclear whether YGJ regulates stem cell differentiation. In this work, we found that YGJ may enhance fetal liver stem/progenitor cell-mediated repair of liver cirrhosis through regulation of macrophage activation state in cirrhosis, suggesting that YGJ in combination with stem cell transplantation may be a suitable treatment for end-stage liver cirrhosis.
Publish Date 2018-11-13 08:04
Citation Xu Y, Fan WW, Xu W, Jiang SL, Chen GF, Liu C, Chen JM, Zhang H, Liu P, Mu YP. Yiguanjian decoction enhances fetal liver stem/progenitor cell-mediated repair of liver cirrhosis through regulation of macrophage activation state. World J Gastroenterol 2018; 24(42): 4759-4772
Url http://www.wjgnet.com/1007-9327/full/v24/i42/4759.htm
DOI http://dx.doi.org/10.3748/wjg.v24.i42.4759
Full Article (PDF) WJG-24-4759.pdf
Full Article (Word) WJG-24-4759.doc
Manuscript File 41221-Review.docx
Answering Reviewers 41221-Answering reviewers.pdf
Audio Core Tip 41221-Audio core tip.mp3
Biostatistics Review Certificate 41221-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 41221-Conflict-of-interest statement.pdf
Copyright License Agreement 41221-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 41221-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 41221-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 41221-Language certificate.pdf
Supplementary Material 41221-Supplementary material.pdf
Peer-review Report 41221-Peer-review(s).pdf
Scientific Misconduct Check 41221-Scientific misconduct check.pdf
Scientific Editor Work List 41221-Scientific editor work list.pdf