Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	43313
Country	Taiwan

Received	2018-11-02 01:58
Peer-Review Started	2018-11-02 09:13
To Make the First Decision	2019-01-14 03:21
Return for Revision	2019-01-15 02:24
Revised	2019-02-23 06:28
Second Decision	2019-02-25 04:52
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-02-25 05:44
Articles in Press	2019-02-25 05:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-02-26 00:18
Publish the Manuscript Online	2019-02-26 08:24

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Surgery
Manuscript Type	Basic Study
Article Title	In vivo expression of thrombospondin-1 suppresses the formation of peritoneal adhesion in rats
Manuscript Source	Unsolicited Manuscript
All Author List	Yun-Sheng Tai, I-Ming Jou, Yun-Chih Jung, Chao-Liang Wu, Ai-Li Shiau and Chih-Yi Chen
Funding Agency and Grant Number
Corresponding Author	Chih-Yi Chen, MD, PhD, Doctor, Doctor, Professor, Institute of Medicine, Department of Surgery, Chung Shan Medical University Hospital, No.110, Sec.1, Jianguo N.Rd,, Taichung 402, Taiwan. neuron6599@gmail.com
Key Words	Intraperitoneal adhesions; Thrombospondin 1; Rat model
Core Tip	Formation of intraperitoneal adhesions is one of the major complications after abdominal surgery, which may lead to bowel obstruction. Thrombospondin-1 (TSP-1) is an extracellular matrix modulating glycoprotein during tissue regeneration and collagen deposition. This study evaluated the therapeutic potential of overexpressed TSP-1 in suppressing pelvic adhesion formations in rat models. We found the application of Sperafilm reduced the formation of adhesion band, and local administration of adenoviral vectors encoding TSP-1 on the injured cecum the also attenuated the severity of peritoneal adhesion score. Therefore, therapeutic approaches in inducing regional overexpression of TSP-1 may serve as alternative treatment strategies for preventing postoperative peritoneal adhesion.
Publish Date	2019-02-26 08:24
Citation	Tai YS, Jou IM, Jung YC, Wu CL, Shiau AL, Chih-Yi Chen CY. In vivo expression of thrombospondin-1 suppresses the formation of peritoneal adhesion in rats. World J Gastrointest Surg 2019; 11(2): 85-92
URL	ttps://www.wjgnet.com/1948-9366/full/v11/i2/85.htm
DOI	https://dx.doi.org/10.4240/wjgs.v11.i2.85

Full Article (PDF)	WJGS-11-85.pdf
Full Article (Word)	WJGS-11-85.docx
Manuscript File	43313-Review.doc
Answering Reviewers	43313-Answering reviewers.pdf
Audio Core Tip	43313-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	43313-Conflict-of-interest statement.pdf
Copyright License Agreement	43313-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	43313-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	43313-Language certificate.pdf
Peer-review Report	43313-Peer-review(s).pdf
Scientific Misconduct Check	43313-Scientific misconduct check.pdf
Scientific Editor Work List	43313-Scientific editor work list.pdf
CrossCheck Report	43313-CrossCheck report.pdf