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3/6/2019 9:24:01 AM | Browse: 468 | Download: 644
Publication Name World Journal of Gastroenterology
Manuscript ID 45018
Country/Territory United Kingdom
Received
2018-12-07 06:09
Peer-Review Started
2018-12-09 13:11
To Make the First Decision
2019-01-11 06:13
Return for Revision
2019-01-14 02:49
Revised
2019-01-17 10:01
Second Decision
2019-01-25 10:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-26 05:34
Articles in Press
2019-01-26 05:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-02-26 07:41
Publish the Manuscript Online
2019-02-27 04:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Current and future pharmacological therapies for managing cirrhosis and its complications
Manuscript Source Unsolicited Manuscript
All Author List David Kockerling, Rooshi Nathwani, Roberta Forlano, Pinelopi Manousou, Benjamin H Mullish and Ameet Dhar
Funding Agency and Grant Number
Funding Agency Grant Number
NIHR
MRC MR/R00875/1
EASL
Corresponding Author Ameet Dhar, BSc, MBBS, MRCP, PhD, Attending Doctor, Liver Unit/Division of Integrative Systems Medicine and Digestive Disease, Imperial College London, 10th Floor, QEQM Wing, St Mary’s Hospital Campus, South Wharf Road, Paddington, London W2 1NY, United Kingdom. a.dhar@imperial.ac.uk
Key Words Cirrhosis; Beta-blockers; Rifaximin; Diuretics; Statins; Proton pump inhibitors; Pharmacology
Core Tip Pharmacological therapy is central to the management of cirrhosis and its complications. Whilst there has been recent debate about the safety of beta-blockade in patients with ascites, conversely there is growing interest in potential benefits relating to a reduction in gut bacterial translocation and hepatocellular carcinoma risk. In addition to its well-established role in treating hepatic encephalopathy, rifaximin may also have a key role in preventing secondary infections. In this review, we summarise these and other uncertainties, controversies and novel developments related to pharmacotherapy in the clinical management of chronic liver disease.
Publish Date 2019-02-27 04:11
Citation Kockerling D, Nathwani R, Forlano R, Manousou P, Mullish BH, Dhar A. Current and future pharmacological therapies for managing cirrhosis and its complications. World J Gastroenterol 2019; 25(8): 888-908
URL https://www.wjgnet.com/1007-9327/full/v25/i8/888.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i8.888
Full Article (PDF) WJG-25-888.pdf
Full Article (Word) WJG-25-888.docx
Manuscript File 45018-Review.docx
Answering Reviewers 45018-Answering reviewers.pdf
Audio Core Tip 45018-Audio core tip.wav
Conflict-of-Interest Disclosure Form 45018-Conflict-of-interest statement.pdf
Copyright License Agreement 45018-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 45018-Grant application form(s).pdf
Peer-review Report 45018-Peer-review(s).pdf
Scientific Misconduct Check 45018-Scientific misconduct check.pdf
Scientific Editor Work List 45018-Scientific editor work list.pdf