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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 45437
Country of Manuscript Source China
2019-01-02 03:24
Peer-Review Started
2019-01-04 04:50
To Make the First Decision
2019-03-18 06:01
Return for Revision
2019-03-26 02:30
2019-04-17 22:07
Second Decision
2019-04-30 07:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-04 02:25
Articles in Press
2019-05-04 02:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-06-13 08:04
Publish the Manuscript Online
2019-06-14 09:43
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript Type Review
Article Title Eukaryotic initiation factor 5A2 and human digestive system neoplasms
Manuscript Source Unsolicited Manuscript
All Author List Qing-Bin Meng, Jing-Jing Peng, Zi-Wei Qu, Xiao-Min Zhu, Zhang Wen and Wei-Ming Kang
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Hubei Province 2016CFB596
Wuhan City Medical Research Project WX15B14
Hubei Province Scientific Research Project WJ2015MB137
Wuhan City Medical Research Project WX16C39
Corresponding author Wei-Ming Kang, MD, Chief Doctor, Professor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai Fu Yuan, Dongcheng District, Beijing 100730, China. kangweiming@163.com
Keywords Eukaryotic translation initiation factor 5A2; Hypusine modification; Acetylation modification; Drug resistance; Cancer therapeutics
Core Tip Eukaryotic initiation factor 5A2 (eIF5A2) is one of only two cellular proteins that contain the unusual amino acid hypusine. eIF5A2 initiates tumor formation, enhances cancer cell growth, increases metastasis, and promotes treatment resistance through inducing epithelial–mesenchymal transition, cytoskeletal rearrangement, angiogenesis, and metabolic reprogramming. Isoform eIF5A2 represents a promising target for treatment of human digestive system cancer. Our objective was to consolidate the current literature to better understand the expression, subcellular localization, post-translational modifications, and regulatory networks of eIF5A2, as well as its biochemical functions and evolving clinical applications in human digestive system cancer.
Publish Date 2019-06-14 09:43
Citation Meng QB, Peng JJ, Qu ZW, Zhu XM, Wen Z, Kang WM. Eukaryotic initiation factor 5A2 and human digestive system neoplasms. World J Gastrointest Oncol 2019; 11(6): 449-458
Url https://www.wjgnet.com/1948-5204/full/v11/i6/449.htm
DOI https://dx.doi.org/10.4251/wjgo.v11.i6.449
Full Article (PDF) WJGO-11-449.pdf
Full Article (Word) WJGO-11-449.docx
Manuscript File 45437-Review.docx
Answering Reviewers 45437-Answering reviewers.pdf
Audio Core Tip 45437-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 45437-Conflict-of-interest statement.pdf
Copyright License Agreement 45437-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 45437-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 45437-Language certificate.pdf
Peer-review Report 45437-Peer-review(s).pdf
Scientific Misconduct Check 45437-Scientific misconduct check.pdf
Scientific Editor Work List 45437-Scientific editor work list.pdf