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10/28/2019 9:38:40 AM | Browse: 26 | Download: 50
Publication Name World Journal of Stem Cells
Manuscript ID 46667
Country of Manuscript Source Sweden
Received
2019-03-12 06:34
Peer-Review Started
2019-03-15 00:16
To Make the First Decision
2019-06-05 06:49
Return for Revision
2019-06-06 05:58
Revised
2019-06-13 15:58
Second Decision
2019-06-19 02:43
Accepted by Journal Editor-in-Chief
2019-06-19 19:16
Accepted by Company Editor-in-Chief
2019-06-20 19:24
Articles in Press
2019-06-20 19:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-06-29 18:35
Typeset the Manuscript
2019-08-22 12:14
Publish the Manuscript Online
2019-08-26 10:16
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Cell Biology
Manuscript Type Review
Article Title Bone marrow microenvironment: The guardian of leukemia stem cells
Manuscript Source Invited Manuscript
All Author List Mohammad Houshmand, Teresa Mortera Blanco, Paola Circosta, Narjes Yazdi, Alireza Kazemi, Giuseppe Saglio and Mahin Nikougoftar Zarif
Funding Agency and Grant Number
Corresponding author Mahin Nikougoftar Zarif, PhD, Associate Professor, Center for Hematology and Regenerative Medicine, Karolinska Institutet, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm 14183, Sweden. mahin.nikougoftar.zarif@ki.se
Keywords Bone marrow microenvironment; Bone marrow niche; Leukemic stem cell; Chronic myeloid leukemia; Acute myeloid leukemia; Target therapy
Core Tip Chronic myeloid leukemia stem cells (LSCs) and acute myeloid leukemia LSCs are resistant to common therapies due to the activation of downstream signaling pathways which guarantee their survival. Also, they are smart enough to escape from immune surveillance. Bone marrow microenvironment (BMM) is behind of all these phenomena by providing an environment which favor leukemia development. Recent studies confirm that targeting LSCs and their crosstalk with the BMM significantly reduces residual disease burden and eventuated in LSCs removal.
Publish Date 2019-08-26 10:16
Citation Houshmand M, Mortera Blanco T, Circosta P, Yazdi N, Kazemi A, Saglio G, Nikougoftar Zarif M. Bone marrow microenvironment: The guardian of leukemia stem cells. World J Stem cells 2019; 11(8):476-490
Url https://www.wjgnet.com/1948-0210/full/v11/i8/476.htm
DOI https://dx.doi.org/10.4252/wjsc.v11.i8.476
Full Article (PDF) WJSC-11-476.pdf
Full Article (Word) WJSC-11-476.docx
Manuscript File FP6887_de5_CE1MS-edit3.docx
Answering Reviewers 46667-Answering reviewers.pdf
Audio Core Tip 46667-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 46667-Conflict-of-interest statement.pdf
Copyright License Agreement 46667-Copyright license agreement.pdf
Peer-review Report 46667-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 46667-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 46667-Scientific misconduct check.pdf
Scientific Editor Work List 46667-Scientific editor work list.pdf