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7/23/2019 6:59:43 AM | Browse: 120 | Download: 58
Publication Name World Journal of Gastroenterology
Manuscript ID 47086
Country of Manuscript Source United Kingdom
Received
2019-03-06 06:49
Peer-Review Started
2019-03-06 08:26
To Make the First Decision
2019-05-17 00:57
Return for Revision
2019-05-20 00:50
Revised
2019-05-22 16:01
Second Decision
2019-05-30 08:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-01 13:21
Articles in Press
2019-06-01 13:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-07-17 00:27
Publish the Manuscript Online
2019-07-19 12:39
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders
Manuscript Source Invited Manuscript
All Author List Alexandre Loktionov
Funding Agency and Grant Number
Correspondence To Alexandre Loktionov, MD, PhD, Director, CEO & Scientific Director, DiagNodus Ltd, 280, Babraham Research Campus, Cambridge CB22 3AT, United Kingdom. alex.loktionov@diagnodus.com
Keywords Eosinophils; Eosinophilopoiesis; Gut lamina propria; Colorectal mucus; Normal human small intestine; Normal human colon; Inflammatory bowel disease; Crohn’s disease; Ulcerative colitis; Colorectal cancer
Core Tip Eosinophils are multifunctional granulocytes possessing readily releasable stores of cytotoxic proteins, regulatory cytokines and chemokines in their specific granules. In health eosinophils reside in the gut, exerting homeostatic functions including protective mucosal barrier integrity maintenance and contribution to gut-associated immunity. Eosinophils are important players in inflammatory bowel disease pathogenesis (both Crohn’s disease and ulcerative colitis). These cells are also associated with a favourable prognosis in colorectal cancer, however mechanisms of this association remain obscure. The author presents a comprehensive analysis of the current literature on eosinophils in the gut and highlights the importance of poorly investigated immune responses occurring within colorectal mucus.
Publish Date 2019-07-19 12:39
Citation Loktionov A. Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders. World J Gastroenterol 2019; 25(27): 3503-3526
Url https://www.wjgnet.com/1007-9327/full/v25/i27/3503.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i27.3503
Full Article (PDF) WJG-25-3503.pdf
Full Article (Word) WJG-25-3503.docx
Manuscript File 47086-Review.docx
Answering Reviewers 47086-Answering reviewers.pdf
Audio Core Tip 47086-Audio core tip.MP3
Conflict-of-Interest Disclosure Form 47086-Conflict-of-interest statement.pdf
Copyright License Agreement 47086-Copyright license agreement.pdf
Peer-review Report 47086-Peer-review(s).pdf
Scientific Misconduct Check 47086-Google-MA RY-1.png
Scientific Misconduct Check 47086-Google-MA RY-2.png
Scientific Misconduct Check 47086-Scientific misconduct check.pdf
Scientific Editor Work List 47086-Scientific editor work list.pdf