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12/3/2019 2:06:51 AM | Browse: 26 | Download: 46
Publication Name World Journal of Gastroenterology
Manuscript ID 51786
Country of Manuscript Source South Korea
Received
2019-10-10 05:48
Peer-Review Started
2019-10-10 05:48
To Make the First Decision
Return for Revision
2019-11-10 05:08
Revised
2019-11-20 07:51
Second Decision
2019-11-22 13:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-22 22:38
Articles in Press
2019-11-22 22:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-11-28 02:51
Publish the Manuscript Online
2019-11-28 10:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Reduced microRNA 375 in colorectal cancer upregulates metadherin-mediated signaling
Manuscript Source Invited Manuscript
All Author List Seol-Hee Han, Ji-Su Mo, Won-Cheol Park and Soo‐Cheon Chae
Funding Agency and Grant Number
Corresponding author Soo‐Cheon Chae, PhD, Professor, Department of Pathology, School of Medicine, Wonkwang University, 460 Iksandae-ro, Chonbuk 54538, South Korea. chaesc@wku.ac.kr
Keywords MicroRNA 375; Metadherin; Mitogen-activated protein kinase; Angiogenesis; Cell proliferation; Colorectal cancer
Core Tip The microRNA 375 (MIR375) is significantly downregulated in human colorectal cancer (CRC) tissues. In this study, we investigated that metadherin (MTDH) is a direct target gene of MIR375 and that MTDH expression levels were upregulated in CRC tissues. Upregulated MTDH expression levels were found to inhibit NF-κB inhibitor alpha expression, which further upregulated NFKB1 and RELA expression in CRC cells. MIR375 also regulate MTDH-mediated BRAF-MAPK and PIK3CA-AKT signal pathways in CRC cells. Consequently, MIR375 regulates cell proliferation, cell migration, and angiogenesis by suppressing MTDH expression in CRC progression.
Publish Date 2019-11-28 10:38
Citation Han SH, Mo JS, Park WC, Chae SC. Reduced microRNA 375 in colorectal cancer upregulates metadherin-mediated signaling. World J Gastroenterol 2019; 25(44): 6495-6507
Url https://www.wjgnet.com/1007-9327/full/v25/i44/6495.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i44.6495
Full Article (PDF) WJG-25-6495.pdf
Full Article (Word) WJG-25-6495.docx
Manuscript File 51786-Review.docx
Answering Reviewers 51786-Answering reviewers.pdf
Audio Core Tip 51786-Audio core tip.m4a
Biostatistics Review Certificate 51786-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51786-Conflict-of-interest statement.pdf
Copyright License Agreement 51786-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 51786-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51786-Language certificate.pdf
Supplementary Material 51786-Supplementary material.pdf
Peer-review Report 51786-Peer-review(s).pdf
Scientific Misconduct Check 51786-Scientific misconduct check.pdf
Scientific Editor Work List 51786-Scientific editor work list.pdf