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3/26/2020 1:54:16 PM | Browse: 388 | Download: 631
Publication Name World Journal of Stem Cells
Manuscript ID 52151
Country/Territory China
Received
2019-11-04 08:56
Peer-Review Started
2019-11-04 08:56
To Make the First Decision
Return for Revision
2019-12-06 05:51
Revised
2019-12-12 03:19
Second Decision
2020-02-14 05:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-02-18 05:44
Articles in Press
2020-02-18 05:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-03-20 07:32
Publish the Manuscript Online
2020-03-26 03:33
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Research & Experimental Medicine
Manuscript Type Review
Article Title Gut commensal bacteria, Paneth cells and their relations to radiation enteropathy
Manuscript Source Invited Manuscript
All Author List Yan-Li Gao, Li-Hong Shao, Li-Hua Dong and Peng-Yu Chang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81874254
National Natural Science Foundation of China 81773353
Corresponding Author Peng-Yu Chang, MD, PhD, Doctor, Department of Radiation Oncology and Therapy, The First Hospital of Jilin University, Xinmin Street, No. 71, Changchun 130021, Jilin Province, China. edvence@163.com
Key Words Gut commensal bacteria; Paneth cell; Radiation enteropathy; Epithelial homeostasis; Gut immunity; Intestinal defense
Core Tip In healthy individuals, Paneth cells restrict the overgrowth of commensal bacteria in the gut while killing luminal pathogenic bacteria by secreting antimicrobial peptides. Such a property protects crypt intestinal stem cells against bacterial infection, thus ensuring epithelial homeostasis in the steady state. Among the active pool of intestinal stem cells, apoptosis commonly occurs as a result of ionizing irradiation. Nevertheless, the intestinal epithelium will recover its integrity after sublethal irradiation. On this basis, the mechanism by which Paneth cells provide growth signals for intestinal stem cells to facilitate epithelial regeneration is easy to understand, whereas the automatic recovery of irradiated intestine from sublethal irradiation is perplexing. Being challenged with luminal bacteria, the degranulation of Paneth cells can be stimulated in a cholinergic- or inflammatory-substance-dependent manner. Then, Paneth cells can perform an antibacterial function that influences the inflammatory milieu in irradiated intestine. Therefore, radiation-induced intestinal bacterial dysbiosis can be managed.
Publish Date 2020-03-26 03:33
Citation Gao YL, Shao LH, Dong LH, Chang PY. Gut commensal bacteria, Paneth cells and their relations to radiation enteropathy. World J Stem Cells 2020; 12(3): 188-202
URL https://www.wjgnet.com/1948-0210/full/v12/i3/188.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i3.188
Full Article (PDF) WJSC-12-188.pdf
Full Article (Word) WJSC-12-188.docx
Manuscript File 52151-Review.docx
Answering Reviewers 52151-Answering reviewers.pdf
Audio Core Tip 52151-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 52151-Conflict-of-interest statement.pdf
Copyright License Agreement 52151-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 52151-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 52151-Language certificate.pdf
Peer-review Report 52151-Peer-review(s).pdf
Scientific Misconduct Check 52151-Scientific misconduct check.pdf
Scientific Editor Work List 52151-Scientific editor work list.pdf